Prolonged Fasting Not Needed 4 Fat Loss, Longevity, Study Finds

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 21 March 2023

⏱️ 10 minutes

🔗️ Recording | iTunes | RSS

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Summary

A new study found daily intermittent fasting for ~ 17-19 hours was sufficient to enhance fat loss, metabolic health and bio-markers linked longevity as well as cancer prevention.

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Link to study, show notes: https://bit.ly/3JqFft4

Time Stamps:

00:00 Fasting 17 to 19 hours per day for 30 days increased autophagy and increased tumor suppressor P53.

02:10 Autophagy increased, favorable changes were made in the inflammasome hub, and there was a decrease in senescence-associated-signaling molecules.

03:00 P53 helps repair DNA damage, prevents senescence, and contributes to reduced atherogenic risk.

06:05 Autophagy has tissue-specific benefits, especially in the liver and brain.

07:35 Regular exercisers have a great increase in fasted-associated autophagy initiation proteins.

08:35 Long duration fasts can catabolize lean mass, possibly increasing risk for cardiovascular disease.

Transcript

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0:00.0	When it comes to fasting, how long do you need to fast to induce levels of
0:02.9	autophagy? Support longevity and decrease inflammation? Well,
0:06.1	it recently published study in 25 individuals found that just 30 days of
0:09.9	Ramadan fasting, that is fasting for 17 to 19 hours per day,
0:14.2	led to significant improvements in levels of autophagy.
0:17.1	And I think this is the most important finding of the study, an increase in a
0:20.0	tumor suppressor protein known as P53. We're going to talk more about that today
0:24.0	and changes in cellular senescence. We know that age cells become senescent,
0:28.4	they release this senescence associated secretory phenotype,
0:31.4	which recruit other cells to become sort of malevolent and
0:35.0	release inflammatory biomarkers. So what this study found is just 30 days,
0:39.4	one month, and it's not hard, 17 to 19 hours of fasting,
0:43.6	led to all these significant improvements that support longevity,
0:46.8	metabolic health, and aging. So let's talk more about this. I think this study is quite
0:50.7	fasting. The title here is the effect of prolonged
0:53.2	intermittent fasting on autophagy, in flamazome, and senescent gene expressions,
0:57.5	and exploratory study in human young males. So investigators in Germany say,
1:01.6	in conclusion, we demonstrate in apparently healthy males who engage in a one-month
1:05.8	Ramadan fasting that prolonged intermittent fasting may induce autophagy,
1:10.1	reduce inflammatory cytokine known as TNF alpha, and reduce senescent markers.
1:14.9	prolonged IF upregulates the expression of NLRP3 in looking one beta,
1:19.6	but not this in flamazome ASC element. And also, our study exhibits dynamic changes
	...

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