Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, Eric Christensen.

Thank you so much for listening. I greatly appreciative to all of you who have shared the podcast

with classmates, students, friends, other healthcare professionals to help grow their knowledge,

background, and their skill set surrounding the use of medications.

So please keep sharing.

If you enjoy the podcast and feel it's relevant and beneficial, I'm greatly appreciative of that.

So let's get into it today.

Probenicid is the drug I'm going to talk about. And I approach this drug cautiously. The title of my

podcast is obviously real-life pharmacology. And I try to bring to you stuff that's used in

clinical practice. Now, I will say I have seen probenicid used in clinical

practice. I would say it's maybe five or ten times at most in my experience. Usually it's been

patients that have been on it for a long time. It's been helpful for them. Or they've had an allergy

or intolerance to other gout medications. So

probenicid primarily is going to be used in the setting of preventing gout flares, okay?

Not the treatment of an active gout flare, but prevention. And it does that by lowering uric acid.

Euric acid is one of the major components that we worry about in patients with frequent gout

flares.

There is one other indication other than gout that I have seen suggested, and that is to increase concentrations of penicillin antibiotics

to enable them to have better effects, basically, on treating an infection.

I've never seen this done personally, but I have heard of it before there.

So just wanted to throw that out there for complete completeness sake.

All right. So mechanistically, how does this drug block uric acid? So if you remember back and

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