Obesity and the new science of weight loss | Dr. Louis J Aronne

ZOE Science & Nutrition

ZOE

Nutrition, Health & Fitness, Education, Science

4.6 • 4.9K Ratings

🗓️ 27 June 2024

⏱️ 58 minutes

🔗️ Recording | iTunes | RSS

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Summary

Obesity is a physiological condition that can be managed with the right education and treatment.

In today's episode, Dr. Louis J. Aronne, a leading expert in obesity research, sheds light on the science behind weight management and obesity treatment.

Dr. Aronne dives into groundbreaking weight loss medications. He also explores how lifestyle and eating habits affect long-term health and why medications combined with dietary changes can unlock transformative results.

Louis J. Aronne, M.D. is a leading authority on obesity and its treatment. He’s a former president of The Obesity Society, which publishes the peer-reviewed scientific journal Obesity, of which Dr. Aronne is an associate editor. He has also authored more than 60 papers and book chapters on the topic.

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Timecodes

00:00 Introduction

01:01 Quickfire questions

03:51 What is obesity?

05:06 What’s the difference between overweight and obesity?

07:38 Why has there been such a quick rise in obesity?

10:55 Why it’s not just a lack of willpower

13:50 The complexity of weight regulation

15:54 What is Leptin and why is it so important for weight control?

19:51 The brain’s role in weight regulation

20:36 Curing obesity in animal studies

22:29 Why hunter-gatherers did not gain weight

23:58 Natural experiments in weight gain and loss

26:01 How medications can cause weight gain

28:42 The impact of calorie restriction diets

30:13 Reducing diabetes risk through weight loss

34:10 Research into medications as a tool for weight loss

38:36 How well do weight loss drugs work?

41:38 The future of weight loss drugs

43:51 Will you regain the weight if you stop taking weight loss drugs?

48:08 Can obesity be avoided without the use of drugs?

49:42 Concerns about weight loss drugs

Books by our ZOE Scientists:

Mentioned in today's episode:

Persistent metabolic adaptation 6 years after "The Biggest Loser" competition in Obesity
The Finnish diabetes prevention study (DPS) in Diabetes Care
The National Diabetes Prevention Program of the Centers for Disease Control and Prevention (CDC)

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Episode transcripts are available here.

Transcript

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0:00.0	Welcome to Zoe, science and nutrition, where world-leading scientists explain how their research can improve your health. Today we're learning all about obesity and weight gain.
0:18.0	When I was growing up, the common belief was that if you gain weight, it's your fault. And if you can't lose that weight, it's also your fault.
0:27.0	Those beliefs are not just harsh, they're untrue. Today's guest has been studying obesity for 35 years and he'll explain why the recent
0:37.1	science means that today we are more able than ever to treat obesity.
0:44.0	Dr Lou Arron is one of America's leading authorities on obesity and how to treat it.
0:50.0	He founded the Comprehensive Weight Control Center at Wild Cornell Medicine,
0:55.0	and in this episode he shares his most exciting breakthroughs on long-term weight management.
1:00.0	Lou, thank you so much for joining me today.
1:05.0	Pleasure.
1:07.0	So we have a tradition here at Zoe,
1:09.1	where we always start with a quick fire round of questions
1:12.1	from our listeners, which means we ask you to give us a yes or a no or if you
1:17.3	absolutely have to a one sentence answer you up for that yeah fantastic all. If I can't lose weight despite trying, is it my fault?
1:27.0	No, never. Is exercise likely to lead to weight loss.
1:33.0	Exercise rarely causes weight loss.
1:36.7	Can gaining weight trick my body into gaining even more weight?
1:41.9	Yes.
1:43.8	Do these new weight loss drugs work?
1:46.2	Absolutely work.
1:47.6	If I am using a weight loss drug,
1:50.0	can I eat whatever I want?
1:51.7	No.
	...

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