NFL Week 5 DraftKings Picks 2025 | Best DFS NFL Lineups, Ownership Projections

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5 • 5.3K Ratings

🗓️ 3 October 2025

⏱️ 91 minutes

🔗️ Recording | iTunes | RSS

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Summary

Pat Mayo and Tyler Tamboline ABD John Breslin of 4for4 DFS Fantasy break down the best 2025 NFL Week 5 DraftKings picks, lineups, and DFS strategy to help you build winning rosters. We cover ownership projections, game stacks, top plays, fades, and Underdog Pick’em picks for Week 5. Whether you’re entering GPPs or cash games, this guide has you covered.

Transcript

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0:00.0	Thank you, the Pat Mayo Experience.
0:04.0	Welcome to the Pat Mayo Experience,
0:05.0	The Weeks Perthew Experience,
0:07.0	Defoe Experience,
0:09.0	Spaniel Experience,
0:10.0	Sparience,
0:11.0	And Sparience!
0:14.0	Welcome to the Pat Mayo Experience, presented by Underdog.
0:18.0	Today we're talking about the week five.
0:20.0	DFS picks on Drafking is going to go through
0:22.3	lineup building, stacking ownership, and making your teams a little bit different than everyone
0:27.2	else's sub to 444.com to get yourself the ownership projections updated in periodic, real time
0:35.1	over the weekend. So once there's injury news, that ends up happening.
0:38.2	You can use the optimizer, all of the tools that are up there.
0:41.0	And you can get John Breslin's full showdown, main slate picks.
0:46.9	John, I mean, you're hammering out each of these slates, aren't you?
0:50.4	Yeah, absolutely.
0:52.2	Good to be back.
0:58.2	So, yeah, I got a new microphone. So if my picks are bad this week, the old microphone was my lucky microphone. But hopefully that won't happen. But yeah,
1:03.0	coming off a pretty good Thursday night game, we saw some overtime. And two of the best players
1:08.5	that are usually on main slate, Christian McCaffrey and Pooka Nakua.
1:27.6	Yeah, so what do we do this week, Tambo? Like, when we take an overview of this slate, like we got a whole bunch of injuries to deal with. Shipatnation.com, by the way, for all of Tampo's work and he's subbed their YouTube channel for even more info on this stuff. but like no McCaffrey no Puka.
	...

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