Hey, all. Welcome back to the Real Life Pharmacology podcast. I am your host, Eric Christensen.

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Hopefully you can pick up some clinical pearls and some good background information on the pharmacology.

So I'm going to cover Monte Lucast or Singular today is the brand name.

And this drug is classified as a leukotrine receptor antagonist.

And so that's, you know, big fancy term, leukotrines.

I wanted to cover that a little bit.

Leucotrines play a really important role in inflammation, in smooth muscle contraction

within the airway. They're also involved in kind of that reaction to an allergen. And

in situations with allergic rhinitis, those leukotriens are increased.

So you could imagine from the mechanism and how we're trying to block or reduce the effects

of leukotriens, you could understand why this medication is useful, beneficial in the

treatment management of allergy type symptoms and or asthma type

symptoms.

Where, again, we've got that inflammation, we've got smooth muscle contraction due to the

leukotrients, so we really want to block those effects.

We want to stop that inflammation and we want to open up those airways in a situation like asthma.

So dosing with this medication, pretty simple, pretty straightforward, 10 milligrams once a day.

In clinical practice, I do not recall a situation where I've ever seen much alteration from that dose, except for maybe in

pediatrics where a lower dose might be considered and or appropriate there. But in adults,

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