Hello again and welcome back to the real-life pharmacology podcast. On today's episode, I'm going to cover

Metaclopramide brand name Reglan. But I do want to remind you that we've had almost a thousand people now

take advantage of our free top 200 study guide on a real life pharmacology.com.

So definitely go there, free download once you've subscribed to the podcast and really just send

weekly updates usually on when a new podcast is available is primarily what we send out there.

So definitely go check that out.

It's a perfect tool for before final exams or board exams,

just kind of going through each of the top 200.

And I pull out three of the most important things you should know from each medication there.

So go check that out.

Let's get into metaclopramide a little bit.

Starting off with the mechanism of action,

and the mechanism of action is going to be really, really important.

So this drug blocks dopamine and can have some serotonin receptor activity as well or blockade

as well.

Now the primary mode of action or where this happens is in the chemoreceptor zone which is

important in regulating the sensation of nausea and vomiting.

So you could imagine that if we're trying to target that area mechanistically,

we're trying to reduce or improve somebody's symptoms of nausea and vomiting,

and indeed that is one of the common uses of metaclopramide.

Now, one other use with this medication is gastroporesis.

So gastroporesis is basically the slowing down of the gut motility and nausea, vomiting, stomach upset can result because of this.

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