Metabolic Health Testing Beyond LDL-Cholesterol: Remnant Lipids Explained

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 17 May 2023

⏱️ 17 minutes

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Summary

Remnant lipoproteins are being recognized as a better proxy for metabolic health.

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00:00 Remnant cholesterol is an atherogenic lipid.
01:10 Remnant cholesterol is linked with metabolic dysfunction.
02:10 Remnant cholesterol is a good assessment for non-alcoholic fatty liver disease, diabetes, hypertension, chronic kidney disease, and atherosclerosis diseases.
02:27 Total cholesterol – HDL – LDL = Remnant Cholesterol.
07:45 Remnant cholesterol levels, with high accuracy, identify metabolic syndrome.
08:50 Remnant cholesterol is a measure of the triglyceride enriched atherogenic lipoprotein.
10:00 Industrialized seed oils increase the propensity of your atherogenic lipoproteins to become oxidized.
10:50 Women have a higher risk of metabolic syndrome related to remnant cholesterol.
11:50 Older women have significantly higher bodyfat percentage, worse lipid profiles, and worse lipid metabolism then men and younger women.
13:30 Skeletal muscle is important to metabolic health.
14:40 Menopausal bioidentical HRT reduces the risk of a number of diseases.

Transcript

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0:00.0	In today's show, we're going to talk about a biomarker that's more sensitive than LDL cholesterol
0:04.1	and indicates your overall metabolic health. It's known as remnant cholesterol. There's a very
0:08.5	simple equation that you can use and we're going to talk about in today's show about how to measure
0:13.0	your remnant cholesterol, both fasting and non-fasting states. We're going to talk about a recently
0:17.5	published paper that is the first paper of its kind to characterize and make associations with
0:22.8	elevated levels of remnant cholesterol and the incidence of metabolic syndrome, which is a
0:27.6	cluster of interrelated cardiometabolic imbalances that are unfortunately quite common amongst
0:34.0	US adults and actually it's increasing in its prevalence in children as well. The title of this
0:39.6	paper is remnant cholesterol can identify individuals at higher risk of metabolic syndrome
0:44.6	in the general population. So it's more sensitive than looking at just your LDL cholesterol.
0:50.2	And so we'll talk about what remnants are. Now, remnant cholesterol is a highly
0:54.4	anthropogenic lipid, which includes a variety of lipoprotein such as chylomicron remnants,
0:59.9	VLDLs, those are the chylomicron remnants, intermediate density lipoprotein,
1:04.5	IDLs, and very low density lipoprotein in a fastened state, also known as triglyceride rich
1:10.8	lipoprotein cholesterol. So what makes the remnants different from LDL cholesterol is that they're
1:16.3	triglyceride enriched and that is a phenomenon that's linked with metabolic dysfunction.
1:22.2	So I would like you to go back to your labs that you've run and if you haven't run them yet,
1:27.2	make sure to get fasted labs first and then do some post-prangial non-fasted lipid load testing.
1:32.2	We've talked about that in other videos. To make a long story short, you have a standardized meal
1:36.2	that you would normally eat that's relatively high in fat, 60 to 70 grams of fat, and you get your
1:40.8	blood work done within the two to three hour window after the meal. It doesn't need to be exactly
1:46.5	precise. Generally, what I'll do is I'll have like a breakfast and then I'll go run my labs about
	...

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