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Welcome to Prognosis. I'm Laura Carlson. It's day 275 since coronavirus was declared a global

pandemic. Today's main story, how do you roll out a vaccine, state by state, to hundreds of millions of people in the middle of a pandemic.

You start with the flu shot.

But first, here's what happened in virus news today.

The first of the first of shots were administered by U.S. hospitals on Monday.

It's the initial step in a historic drive to immunize millions of people as deaths in the U.S. approach the 300,000 mark.

The first shot went to critical care nurse Sandra Lindsay in New York, the city that was once the epicenter of the pandemic. Hospitals around the country went into overdrive this weekend, preparing to receive and administer the first doses of the vaccine.

Shipments started leaving Pfizer's Michigan plant early on Sunday morning, less than two days after the Food and Drug Administration authorized the vaccine for emergency use. They are scheduled

to arrive at hundreds of sites between today and Wednesday. Italy overtook the UK as the European

country with the highest number of COVID-19 deaths. The death toll puts pressure on Prime Minister Giuseppe Conti's government,

as it seeks to prevent a flare-up of the contagion during the holiday season.

Finally, Pfizer and Bio-Antec may soon allow participants in its vaccine trial to learn

whether they received a placebo rather than the real thing, and get the actual

shot if they wish. In an emailed statement, Pfizer said the option would be voluntary.

And now for today's main story.

As the first shots of the COVID-19 vaccines in the U.S. are administered, one of many big hurdles has yet to be cleared.

States must transport and distribute the massive orders to the millions who need it.

The state of Louisiana has been thinking about this problem for months.

...