LDL-Cholesterol is USELESS! Measure this Instead: ApoB

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Fasting, Nutrition, Autophagy, Ketogenic, Keto, Health & Fitness, Ketodiet, Medicine

4.8 • 1.2K Ratings

🗓️ 13 April 2023

⏱️ 19 minutes

🔗️ Recording | iTunes | RSS

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Summary

Emerging data suggests using is ApoB as well as the ApoB/ ApoA1 ratio more accurately assess cardiometabolic disease risk than standard LDL-cholesterol testing.

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----------------Show Notes-------------------------------

0:00 Intro
0:03 Standard LDL cholesterol measurements are estimates.
0:15 Every atherogenic lipoprotein has one ApoB100.
1:10 ApoB is causally related to atherosclerosis.
2:08 Optimal ApoB is under 60.
4:05 LDL measurements do not correlate to risk.
6:40 Biomarkers of oxidative stress are linked with risk of atherosclerosis.
7:30 Focus on ApoB levels and the ratio or ApoB to apoA1.
8:50 Many people who die of heart disease have low or normal LDL cholesterol.
10:15 Look for biomarker patterns.
11:30 Atherogenic cholesterol is made by your liver.
12:43 Prevent oxidation and do not ingest oxidated seed oils.
15:30 Triglycerides skew LDL measures.

Transcript

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0:00.0	I think it's fair to say that LDL cholesterol measurements are now obsolete.
0:03.6	I know that might sound like a bold statement because you've gone to your main
0:06.3	tree medical doctor. You were told that your LDL cholesterol levels are concerning,
0:10.4	so you might need to go on certain medications. Well, I'm going to tell you a little bit more
0:13.8	about what is actually going on. We're going to focus on apoliproprotein B, which is a
0:18.2	protonaceous compound on the extracellular surface of all of the pathogenic
0:22.5	liproprotein particles that are floating around in your body.
0:25.6	The LDL cholesterol measurement that you get from your doctor or the hospital,
0:29.2	it's actually an estimate known as the freed walled equation, which gets more and more inaccurate,
0:34.8	the more and more metabolically and healthy you get. This is widely recognized. We need to
0:39.0	reframe the paradigm away from just looking at mathematical estimations for your LDL cholesterol
0:45.1	and focus on apob. I know this sounds like a big multicellabic word apoliproprotein B.
0:51.0	The concepts are very simple. This is a really affordable test and we're going to talk more about
0:55.2	what apoliproprotein B is, what it does, and why it's more sensitive and specific than just
1:00.4	measuring LDL cholesterol. There's many papers out here on apoliproprotein B and it's links with
1:06.0	cardiovascular disease, but suffice it to say the research is quite clear. Apoliprotein B is
1:11.2	causally related to atherosclerosis, the process of the narrowing and the occlusion of your
1:17.2	vessels, including the coronary artery, which is linked to major cardiovascular events. So it's
1:22.0	important that you understand and know your apob levels not just looking at your LDL cholesterol
1:28.2	estimates via the free walled equations. So the paper that we're going to dive into today
1:33.2	is titled apoliproprotein B and cardiovascular disease, biomarkers and potential therapeutic
1:38.4	target. Here's a screenshot of my own measurements. I've been measuring my apob since 2009.
	...

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