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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Lansoprazole Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 23 June 2022

⏱️ 11 minutes

🧾️ Download transcript

Summary

Lansoprazole is a proton pump inhibitor that can be commonly used for GERD, PUD, and GI prophylaxis.



Lansoprazole can inhibit CYP2C19 which can cause concentrations of drugs like escitalopram and citalopram to rise.



Hypomagnesemia, low B12, osteoporosis, and an increase in C. Diff risk are potential complications with longer-term PPI use.



PPIs like lansoprazole are best given 30-60 minutes before meals. This is something that patients often forget.



I discuss important drug interactions on the podcast, be sure to check out my latest project which is a 200+ page book on managing drug interactions in primary care.



Be sure to check out our free Top 200 study guide – a 31-page PDF that is yours for FREE!

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, pharmacist, Sarah Christensen,

0:04.9

and I thank you so much for listening today. As always, go check out Real Life Pharmacology.com.

0:10.9

Get your free 31-page PDF on the top 200 drugs. Great study guide, great resource, great refresher,

0:17.8

no matter where you're at in practice practice or whether you're a student studying for

0:22.3

board exams in nursing and pharmacy and med schools. So go take advantage of that, sign up at

0:28.9

real-life pharmacology.com simply in emails all it's going to take for you to get access to that.

0:34.2

So kind of a no-brainer there. So with that, let's get into the drug of the day.

0:40.2

And that is Lansopazol. Brand name of this medication is Previsid. This is a P.T. Excuse me, a PPI,

0:49.2

so proton pump inhibitor. Ultimately, it blocks proton pumps in the gut, the stomach, and those

0:57.8

pumps are essentially responsible for producing hydrogen ions, pumping hydrogen ions into

1:04.9

the stomach, which gives it its acidic environment. So if we block those pumps, naturally we are going to raise the pH and the stomach will be

1:18.0

less acidic, which is hopefully going to help with things like heartburn, stomach ulcers,

1:25.0

and things of that nature.

1:26.7

So indications, what do we use this for?

1:29.2

Obviously, like I mentioned, you know, heartburn, GERD,

1:32.8

Peptic ulcer disease, GI prophylaxis and prevention.

1:36.3

You'll see that a lot in patients who are anemic

1:39.3

and maybe on higher risk meds like anticoagulants,

1:42.5

Ns, you'll definitely see PPI's like Lensopra's

1:45.9

all used for that. Other situations, Barrett's esophagus, Zolinger-Ellinson syndrome, just generalized dyspepsia,

1:55.1

you definitely see these drugs used a ton in clinical practice.

2:01.7

Dosing of Lensopresol, usually 15 to 30 milligrams once a day is what I typically see for most

...

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