Journal Review in Endocrine Surgery: Parathyroidectomy for Fracture Risk

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 18 August 2025

⏱️ 29 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Primary hyperparathyroidism is an underdiagnosed condition which leads to decreased bone mineral density, fracture, renal disease, among other symptoms that can decrease the quality of a patient’s life. Moreover, once diagnosed, only a small fraction of patients with the diease end up being offered surgery. Whether it is because of misunderstood indications and benefits of surgery, non-localization of disease, or various other reasons, we thought it was worthwhile to review relevant literature.

Hosts: Dr. Becky Sippel is an endowed professor of surgery at Division Chief of endocrine surgery at University of Wisconsin Madison and she is the most recent past president of the AAES. She is an internationally recognized leader in the field of endocrine surgery. She has over 250 publications. She was the PI for a RCT which studies prophylactic central neck dissections which is a widely read and quoted study in endocrine surgery.

Dr. Amanda Doubleday is a fellowship trained endocrine surgeon in private practice with an affiliation to UW Health. Her primary practice is with Waukesha Surgical Specialists in Waukesha WI.

Dr. Simon Holoubek is a fellowship trained endocrine surgeons affiliated with UW Health. He works for UW Health with privileges at UW Madison and UW Northern Illinois. His clinical interests are aggressive variants of thyroid cancer, parathyroid autofluorescence, and nerve monitoring.

Learning Objectives:
1 Understand the natural history of primary hyperparathyroidism and how the disease process can affect bone mineral density.

2 Learn about fracture risk associated with primary hyperparathyroidism.

3 Learn about decreased fracture risk in patients with primary hyperparathyroidism who have parathyroidectomy compared to those who are observed.

References:
1 Rubin MR, Bilezikian JP, McMahon DJ, Jacobs T, Shane E, Siris E, Udesky J, Silverberg SJ. The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years. J Clin Endocrinol Metab. 2008 Sep;93(9):3462-70. doi: 10.1210/jc.2007-1215. Epub 2008 Jun 10. PMID: 18544625; PMCID: PMC2567863. https://pubmed.ncbi.nlm.nih.gov/18544625/
2 Frey S, Gérard M, Guillot P, Wargny M, Bach-Ngohou K, Bigot-Corbel E, Renaud Moreau N, Caillard C, Mirallié E, Cariou B, Blanchard C. Parathyroidectomy Improves Bone Density in Women With Primary Hyperparathyroidism and Preoperative Osteopenia. J Clin Endocrinol Metab. 2024 May 17;109(6):1494-1504. doi: 10.1210/clinem/dgad718. PMID: 38152848. https://pubmed.ncbi.nlm.nih.gov/38152848/
3 VanderWalde LH, Liu IL, Haigh PI. Effect of bone mineral density and parathyroidectomy on fracture risk in primary hyperparathyroidism. World J Surg. 2009 Mar;33(3):406-11. doi: 10.1007/s00268-008-9720-8. PMID: 18763015. https://pubmed.ncbi.nlm.nih.gov/18763015/

Please visit https://behindtheknife.org to access other high-yield surgical education podcasts, videos and more.

If you liked this episode, check out our recent episodes here: https://app.behindtheknife.org/listen

Transcript

Click on a timestamp to play from that location

0:00.0	Behind the Night, the Surgery Podcast, relevant and engaging content designedergery team from the University of Wisconsin, and we are doing a journal
0:28.5	club where we're going to talk about primary hyperparathyroidism and how patients benefit from
0:33.7	parathyroidectomy. Today we're going to be presenting two cases and three journal articles.
0:40.6	Hi, my name is Amanda Doubleday. I'm an endocrine surgeon in a private practice affiliated with the
0:47.2	University of Wisconsin. I'm a fellowship trained endocrine surgeon, and I will be here today for the
0:52.7	discussion of parathyroidectomy, and its benefit on skeletal system and
0:58.0	bone loss.
1:00.3	And I'm Simon Polobeck, I'm a fellowship trained endocrine surgeon, board certified general surgeon,
1:05.7	affiliate with University of Wisconsin Health, and I also have a focused practice in endocrine surgery. And our senior
1:12.3	surgical perspective today will come from Dr. Becky Sipple, who's an endowed professor of surgery
1:17.5	and division chief of endocrine surgery at University of Wisconsin-Madison and the most
1:22.2	recent past president of the American Association of Endocrine Surgeons.
1:27.2	Thanks so much for having me be part of this. I'm really excited to be here. Parathyorectomy is a
1:32.5	huge part of my practice and something I'm really passionate about and I'm excited to share some
1:36.8	of my insights. So I'm looking forward to the discussion.
1:40.8	Our team has no relevant disclosures on this topic today.
1:45.0	Primary hyperparathiridivism is an under-diagnosed condition which leads to decreased bone mineral
1:50.0	density, fractures, kidney disease, among other symptoms that can decrease the quality of
1:55.9	our patient's lives. Moreover, once diagnosed, only about a quarter of patients end up being offered a
2:01.7	parathyroidectomy, whether it's for a variety of reasons, including misunderstood indications,
2:07.6	misunderstood benefits of surgery, non-localized disease, or for other reasons, we thought it was
2:14.4	worthwhile to review the relevant literature demonstrating this
	...

Transcript will be available on the free plan in 22 days. Upgrade to see the full transcript now.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Behind The Knife: The Surgery Podcast, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Behind The Knife: The Surgery Podcast and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.