Journal Review in Breast Surgery: Management of Residual Disease After Neoadjuvant Chemotherapy

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 13 December 2021

⏱️ 19 minutes

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Summary

Why should a surgeon care about breast cancer chemotherapy trials? Join Drs. Michael Alvarado, Rita Mukhtar, and Alexa Glencer as they discuss the benefits of neoadjuvant chemotherapy over upfront surgery and the role of adjuvant chemotherapy for select patients who harbor residual disease at the time of surgery.

Learning objectives:
- Understand the benefits conferred by neoadjuvant chemotherapy compared to upfront surgery in certain patients with breast cancer
- Learn about the study design and results of the CREATE-X phase 3 randomized controlled trial comparing adjuvant capecitabine to standard therapy in patients with HER2 negative invasive breast cancer with residual disease following cytotoxic neoadjuvant chemotherapy
- Describe the specific benefit of adjuvant capecitabine for triple negative breast cancer patients and discuss its evolving role with recent FDA approval of neoadjuvant pembrolizumab in this group
- Learn about the study design and results of the KATHERINE phase 3 randomized controlled trial comparing adjuvant T-DM1 to trastuzumab in patients with HER2+ invasive breast cancer with residual disease following cytotoxic and HER2-targeted neoadjuvant chemotherapy

Journal article links:
CREATE-X: https://www.nejm.org/doi/full/10.1056/NEJMoa1612645
KATHERINE: https://www.nejm.org/doi/full/10.1056/NEJMoa1814017

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Transcript

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0:00.0	David Mitchell, six comedians, one googling contest of survival.
0:05.6	I thought it was quite a pleasant week.
0:07.2	Deadly weapons.
0:08.4	Two scissors count. There was a lot of arts and craft.
0:11.2	Death-defying stunts.
0:13.2	If that's a reference to me tripping over, I've been assured by the producers they've cut it.
0:16.8	Dangerous obstacles.
0:18.4	There are a lot more nettles than I would have liked.
0:20.4	It's survival of the funniest.
0:22.4	Let's see what you've done there.
0:23.6	David Mitchell's outsiders.
0:26.0	Tonight at 10 on Dave and UK TV Play.
0:30.4	Behind the knife.
0:37.2	The surgery podcast.
0:39.2	Relevant and engaging content designed to help you.
0:42.0	Dominate the day.
0:53.2	Hello, it's great to be back on behind the knife.
0:55.2	Today, Dr. Alvarado, Dr. Maktar and I will be hosting our first
0:59.2	breast surgical oncology journal club.
1:01.6	As a reminder, my name is Alexa Glenser.
1:04.0	I'm an R4 general surgery resident at UCSF.
1:08.0	Dr. Alvarado is a professor of breast and melanoma surgery.
	...

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