Jan 24 2025 This Week in Cardiology

This Week in Cardiology

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4.9 • 876 Ratings

🗓️ 24 January 2025

⏱️ 26 minutes

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Summary

Familial hypercholesterolemia, cardiac arrest therapy, Factor XI inhibition, and tricuspid valve interventions are the topics John Mandroa, MD, discusses in this week’s podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I. Familial hypercholesterolemia

Danish Registry Study: https://doi.org/10.1093/eurheartj/ehae912

II. Cardiac Arrest

Vallentin and Colleagues RCT https://www.nejm.org/doi/full/10.1056/NEJMoa2407616

III. Factor XI

AZALEA https://www.nejm.org/doi/full/10.1056/NEJMoa2406674
OCEANIC https://www.nejm.org/doi/full/10.1056/NEJMoa2407105
VTE Study of Abelacimab 2021 https://www.nejm.org/doi/10.1056/NEJMoa2105872

IV. Tricuspid Valve Interventions

TRILUMINATE 1-year Study https://doi.org/10.1016/j.jacc.2024.10.086
Stone Editorial https://doi.org/10.1016/j.jacc.2024.11.045
TRISCEND Main Paper https://www.nejm.org/doi/full/10.1056/NEJMoa2401918
QOL Paper https://doi.org/10.1016/j.jacc.2024.10.067
PASTE Registry https://doi.org/10.1016/j.jacc.2024.10.068
AL-Lamee Editorial https://doi.org/10.1016/j.jacc.2024.10.085

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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact [email protected]

Transcript

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0:00.0	You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.
0:05.7	This podcast is intended for health care professionals only.
0:08.8	Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.
0:15.8	Hi, everyone.
0:17.1	This is John Mandrola from the Heart.org Medscape Cardiology, and this is this week
0:22.1	in cardiology for January 24th, 2025. This week, familial hypercholesterolemia, cardiac arrest therapy,
0:31.2	factor 11 inhibition, and more on tricuspid valve interventions. I first want to say thank you to the University of Michigan
0:39.0	Fellows for inviting me to give cardiovascular rounds there yesterday. It is an honor to be asked
0:44.4	to speak anywhere, but is an especially big honor to get a fellow's invite. I spoke on atrial fibrillation
0:51.4	therapy focusing on areas of uncertainty. It was also great to see
0:57.0	my friend, Vanke Murthy, who's a true academic. All right, first topic today is familial
1:03.5	hypercholomia. When I started cardiology many years ago, getting the diagnosis of FH was terrible.
1:10.4	Early coronary disease and cardiovascular death
1:12.5	was highly likely. But things have changed for the better. So suggests yet another neat observational
1:20.9	comparison study using that national treasure the Danish Health Registry. The first author is Jacob Re, and co-authors from the Genthoff Hospital in Copenhagen,
1:31.9	which I've visited.
1:33.7	They use the registry to compare about 11,000 patients with and 9 million without FH
1:39.7	over a 45-year period dating back to 1978.
1:48.1	During follow-up, 27% of those with and without femal hypercalycelestralia died. And the key findings for individuals with FH compared to those without,
1:56.6	the mean age at death was 22 years younger in 1978, but in 2021, the corresponding difference
2:05.7	in mean age of death was only one year, 78 versus 79 years.
2:10.9	And when you look at a graph with age of death on the y-axis, and years on the x-axis,
	...

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