Jan 14, 2022 This Week in Cardiology Podcast
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 14 January 2022
⏱️ 16 minutes
🧾️ Download transcript
Summary
Xeno-transplantation, weight loss drugs, DOAC coverage, vitamin D, LAAC and frailty, and recalled LVADs are the topics John Mandrola, MD, discusses in this week's podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
I – Xenotransplantation
- Pig Heart Successfully Transplanted to Man https://www.medscape.com/viewarticle/966367
- What Does a Pig-to-Human Heart Transplant Mean for Medicine? https://www.medscape.com/viewarticle/966488
II – Weight Loss Drugs
- Wegovy Tops Sibling Saxenda for Weight Loss https://www.medscape.com/viewarticle/966376
- Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes https://jamanetwork.com/journals/jama/article-abstract/2787907
III – DOAC Coverage
- CVS Caremark Formulary Change Freezes Out Apixaban https://www.medscape.com/viewarticle/966588
IV – Vitamin D
- More Vitamin D Not Better for Reducing Cancer or CVD Incidence https://www.medscape.com/viewarticle/966333
- The D-Health Trial: a randomised controlled trial of the effect of vitamin D on mortality https://doi.org/10.1016/S2213-8587(21)00345-4
- Vitamin D supplementation and prevention of cardiovascular disease and cancer in the Finnish Vitamin D Trial—a randomized controlled trial https://doi.org/10.1093/ajcn/nqab419
- Association between vitamin D supplementation and mortality: systematic review and meta-analysis https://www.bmj.com/content/366/bmj.l4673
V – LAAC and Frailty
- Frailty in patients undergoing percutaneous left atrial appendage closure https://doi.org/10.1016/j.hrthm.2022.01.007
- Net Clinical Benefit of Left Atrial Appendage Closure Versus Warfarin in Patients With Atrial Fibrillation: A Pooled Analysis of the Randomized PROTECT-AF and PREVAIL Studies https://pubmed.ncbi.nlm.nih.gov/31752643/
VI – LVAD recall
- A High-Risk Medical Device Didn't Meet Federal Standards. The Government Paid Millions for More. https://www.medscape.com/viewarticle/966255
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Transcript
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| 0:00.0 | You're listening to this week in cardiology from the heart.org on medscape. |
| 0:09.7 | You can now access the latest in medical news on your Amazon Alexa enabled device. |
| 0:14.3 | Join me, Perry Wilson, every weekday morning for Medscape Medical Minute, where I highlight |
| 0:18.8 | the top medical stories of the day. |
| 0:21.1 | To add Medscape Medical Minute to your flash briefing, search for Medscape |
| 0:24.4 | Medical Minute on Amazon and click enable. Or open the Amazon Alexa app, go to |
| 0:29.0 | skills, search for Medscape Medical Minute and click enable. Then say, |
| 0:33.4 | Alexa, what's the news or Alexa, what's my flash briefing? I hope you'll join us. |
| 0:38.6 | Hi everyone, this is John Mandrola from the Heart.org Medscape Cardiology, and this is this week in |
| 0:45.1 | Cardiology for January 14, 2022. |
| 0:49.4 | This week, xenotransplantation, weight loss drugs, |
| 0:53.4 | doax, Vitamin D, left atrial appendage closure, |
| 0:57.8 | and recalled Elvads. |
| 1:00.5 | First is the pig heart transplant. |
| 1:03.0 | Wow, I just don't know what to say. |
| 1:06.0 | I mean previous attempts that xenotransplantation failed due to rejection. |
| 1:10.0 | This time, the pig heart was seriously genetically modified to help prevent rejection. |
| 1:16.0 | Get this, three genes associated with anybody mediated rejection had been knocked out in the pig supplying the transplanted heart, and six human genes associated |
| 1:25.6 | with immune acceptance of the organ had been inserted into the pigs genome. |
| 1:30.0 | I mean if this works, even over the short term term it seems more a story about molecular biology and gene modification therapy than transplant and I know it sounds crazy and perhaps this is but but I always like to remind my younger listeners that when I was in |
| 1:46.0 | training by ventricular pacing and AF ablation were not only not invented but |
| 1:50.6 | had not yet been conceived of. |
... |
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