Welcome back to another episode of the talk today. We are back with Professor Serafini, and I have a couple more questions for you. So first, a more sciencey question, because it relates to what we talked about in our main episode, and then I have some more fun questions. But first of all, I want to talk about this idea of obesity and having this chronic inflammation.

The classic understanding, at least for me, of obesity was always that it came down to an

excess of calories. And because you ate all these extra calories, you were storing more fat,

and then basically having increased fat stores was what was causing this increase in inflammation. But it sounds like,

at least as our understanding of obesity evolves, that it's not just about the calories, and it's

has all these other things that we don't really understand yet, and these other pathologies that

make it a disease and not just

excess weight. Do we know how the inflammatory state relates to excess calories or like does it

always have to do with eating too much or can there be inflammatory states if you're not obese

just you're eating the wrong foods? Are you always an inflammation? Like, how does this two things

relate? Absolutely. That's a key question. And I'm glad that you asked me about it because,

you know, clearly, as you say, you know, we are, we have the idea that it's correct, you know,

that if we eat too much, we get obese, inflammation, and all the problems.

But of course, obesity is not just matter of eating too much.

It could be related to certain alteration in gene expression, many, many aspects.

But the point is that also if you are not obese, you can be under inflammatory stress.

That's the point.

Maybe you are only overweight or that's why we have the metabolic syndrome.

If you think about the metabolic syndrome that become a pathology, it was not a pathology.

The idea of metabolic syndrome that is actually now a pathology, meaning that

you have at least three cardiovascular risk factors. That could be high level of lipids or

glycemia or fat, obesity, BMI or blood pressure. If you have three of that, you are in metabolic syndrome.

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