Insulin Resistance Fuels Artery-Clogging Plaque, Early Atherosclerosis
High Intensity Health with Mike Mutzel, MS
Mike Mutzel
4.8 • 1.2K Ratings
🗓️ 25 May 2024
⏱️ 14 minutes
🧾️ Download transcript
Summary
A new study finds insulin resistance and reduced glucose uptake in the heart is linked with early-onset atherosclerosis and heart issues.
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Research Mentioned:
Devesa, A. et al. Cardiac Insulin Resistance in Subjects With Metabolic Syndrome Traits and Early Subclinical Atherosclerosis. Diabetes Care 46, 2050–2057 (2023).
Time Stamps:
00:00 FDG = Fluorodeoxyglucose
00:30 Reduced glucose uptake in the heart is tethered to atherosclerosis.
01:20 LDL levels are not strongly associated with poor outcomes.
02:00 Your heart becomes insulin resistant.
03:05 Those with no glucose uptake in the heart had higher fasting glucose.
03:45 Those with more cardiovascular risk factors had lower LDL.
04:35 The heart can generate energy from fatty acids, carbs, and ketones.
05:00 Cardiac abnormalities are associated with metabolic syndrome.
07:00 Insulin resistance changes muscle and heart muscle.
09:16 Insulin resistance is associated with a progressive decrease of myocardial FDG uptake.
09:50 Cardiovascular risk increases with the decline of FDG uptake.
11:30 Your heart loses the ability to pump blood effectively as it loses ability to utilize different energy substrates.
12:40 Support your heart by supporting your metabolism.
Transcript
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| 0:00.0 | A new study finds insulin resistance within the heart is exacerbating the process of atherosclerosis |
| 0:05.5 | leading to the high burden of cardiovascular disease. |
| 0:08.6 | This is the first study of its kind looking at what's known as FDG which is |
| 0:13.1 | fluoreoxy glucose uptake within the heart. |
| 0:16.3 | This is a fancy tool that's utilized mainly |
| 0:19.2 | in the context of cancer to look at the uptake of glucose |
| 0:22.4 | and neoplastic cells, but these investigators |
| 0:25.3 | wanted to see if individuals with insulin resistance, i.e. metabolic |
| 0:29.8 | syndrome characteristics, if they had low uptake of glucose within their heart because it turns |
| 0:35.8 | out that the heart should be metabolically flexible and in subjects that are insulin resistant because |
| 0:40.8 | they have central adiposity, |
| 0:42.6 | belly fat, increased blood pressure, increased glucose, |
| 0:46.1 | changes within their lipids and so forth. |
| 0:48.6 | The investigators found that there was a reduction |
| 0:51.6 | in the glucose uptake in the heart and that was strongly tethered |
| 0:55.7 | to the process of atherosclerosis leading to poor events over time. |
| 1:00.9 | Now these individuals were part of the what's known as the PISA study, the progression for early subclinical atherosclerosis study cohort out of Spain. There was 800 subjects that were tracked for five years. And before we go on let's look at the graphical |
| 1:14.4 | abstracts we have a better idea of what these investigators we're trying to |
| 1:17.6 | figure out here. I think this is pretty interesting stuff because we hear so much |
| 1:21.1 | about lipids. We've taught ad nauseum about how |
| 1:23.8 | LDL, despite the fact that the mainstream medical profession is monotonically |
| 1:28.6 | focused on lowering aldial cholesterol, we know there's not a strong statistical |
... |
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