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High Intensity Health with Mike Mutzel, MS

Insulin Resistance Causes Muscle Loss, New Research Finds

High Intensity Health with Mike Mutzel, MS

Mike Mutzel

Nutrition, Medicine, Health & Fitness

4.71.3K Ratings

🗓️ 8 May 2022

⏱️ 18 minutes

🧾️ Download transcript

Summary

Aging naturally causes muscle loss, and poor metabolic health hastens the process. Learn how to break this viscous cycling and preserve muscle as you age.


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Links to research, video and show notesh: https://bit.ly/383kKUD

Time Stamps

0:26 You become less glucose tolerant as you age.
0:49 Insulin resistance amplifies the rate of acceleration in the wasting of muscle.
1:05 Muscle stem cells, as you age, cause your muscles to behave like fat tissue.
1:25 Muscle tissue of people who are insulin resistant or diabetic resembles that of age-related sarcopenia.
1:35 Atrogenes drive atrophy.
1:52 60 to 80% of post meal glucose is deposited in skeletal muscle. If there is no muscle, it gets converted into fat.
2:45 About 83% of American adults suffer from some sort of insulin resistance.
3:25 Insulin resistance favors muscle protein catabolism, at the expense of muscle protein synthesis.
6:18 Insulin resistance activates atrophy genes.
6:50 You become more insulin resistant and lose muscle mass as you age.
7:40 Hyperinsulinemia accelerates atherosclerosis (heart disease) and cancer.
10:58 Insulin resistance leads to a decline of mTOR activation in your muscle.
13:00 About .1% of all of your muscle tissue is turning over at any point. Progenitor stem cells are involved in the maintenance and regeneration of your muscles.
14:00 Muscle is the most active site of protein metabolic processes in the body.
14:25 You may get better gains from exercise and resistance training by being more insulin sensitive.
15:10 Background inflammation from insulin resistance can accelerate muscle atrophy.
16:00 To become more insulin sensitive…

Transcript

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0:00.0

Hey friends, welcome back.

0:01.0

So in today's show, we're going to talk more about the connections between insulin resistance

0:04.6

as a main driver of age-related muscle loss.

0:07.2

I came across this fascinating new paper, and I want to share with you some nitty-gritty

0:10.5

details so that we can all better understand the importance of preserving lean muscle mass

0:15.2

as a way to protect and preserve and restore metabolic health that is so important as we

0:20.8

age.

0:21.8

Because as we've talked about before, as you age, naturally you become less glucose tolerant.

0:26.5

So you become more metabolically unhealthy just as a fact of living a long life, right?

0:31.9

So we want to preserve that metabolic integrity throughout lifespan.

0:35.3

And it turns out that preserving the health of your muscle is very important.

0:39.2

It protects from all-cause mortality, cardiovascular disease, and cancer-related deaths.

0:44.4

But in this paper, as they describe, insulin resistance actually turns on or amplifies

0:49.5

the rate of acceleration and wasting of muscle, which creates this vicious cycle of more

0:55.8

insulin resistance, poor glucose tolerance, and actually increase risk of mortality from

1:01.0

age-related muscle loss.

1:02.5

In fact, we're going to talk about how the muscle stem cells become sort of tweaked, and

1:07.0

as you become more insulin resistant, those stem cells start to turn the muscle cells,

1:11.8

these progenitor satellite cells, to cause your muscle cells to behave like fat tissue,

1:16.6

like adipocytes.

1:18.1

In fact, individuals who have been diagnosed or have prediabetes or diabetes, their muscle

1:23.0

tissue resembles that of age-related sarcopenia.

...

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