All right, so welcome back to the Internet Book of Critical Care podcast.

I'm here with Adam Thomas and we're going to talk about acetaminophen poisoning.

Tylenol or Cetaminophen.

This one you need to know cold because it's one of our most common overdoses where toxicity seen.

And it's one of those fun ones, isn't it, Josh,

where we can actually fix it. Well, it's interesting because toxicology, we're always looking

for antidotes and most of our antidotes are kind of unimpressive, but this one actually works.

It's a hero of an antidote. It works so well. So today we're going to cover the epidemiology

in pharmacokinetics. We'll talk about that clinical evolution and patient evaluation.

We'll talk about who needs decontamination.

We'll talk about who needs treatment and then segue into all things NAC, that wonderful

antidote that we have for acetaminifin.

New post section here is massive acetaminophen poisoning.

Josh has referenced to this and a lot of people don't talk about this, which is a lot of fun.

And then some nuances around how to manage those specific patient populations of hepatic and renal failure patients.

So Josh, let's get into the nitty gritty that epidemiology and pharmaconetics. Talk to me about the basics and specifically what's going on

with our pathways from APAP to NAPK. To start off with epidemiology, there are basically two groups

of patients that you're going to see with the cinnamon and poisoning. One group are the suicide

attempt folks who often present relatively soon. They often will take it and regret it, show up to

the emerge. And these patients are going to be straightforward as far as diagnosis goes. But that's only 50% of your patients. The other half

of patients are patients with unintentional poisoning. These are often your chronic pain patients who are

taking some weird percocet or some combination pills along with the acetaminopin. They can be

...