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TED Talks Daily

How we could teach our bodies to heal faster | Kaitlyn Sadtler

TED Talks Daily

TED

Creativity, Business, Design, Inspiration, Society & Culture, Science, Technology, Education, Tech Demo, Ted Talks, Ted, Entertainment, Tedtalks

4.111.9K Ratings

🗓️ 20 September 2018

⏱️ 5 minutes

🧾️ Download transcript

Summary

What if we could help our bodies heal faster and without scars, like Wolverine in X-Men? TED Fellow Kaitlyn Sadtler is working to make this dream a reality by developing new biomaterials that could change how our immune system responds to injuries. In this quick talk, she shows the different ways these products could help the body regenerate.

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Transcript

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0:00.0

This TED Talk features regenerative tissue engineer Caitlin Sadler, recorded live at TED 2018.

0:08.0

What if you could take a pill or a vaccine, and just like getting over a cold, you could heal your wounds faster?

0:16.0

Today, if we have an operation or an accident, we're in the hospital for weeks and often left with scars and painful side effects of our inability to regenerate or regrow healthy uninjured organs.

0:30.6

I work to create materials that instruct our immune system to give us the signals to grow new tissues.

0:41.3

Just like vaccines instruct our body to fight disease, we could instead instruct our immune system to build tissues

0:45.3

and more quickly heal wounds.

0:47.3

Now, regrowing body parts out of nowhere might seem like magic,

0:51.3

but there's several organisms that can achieve this feat. Some lizards can

0:55.3

regrow their tails. The humble salamander can completely regenerate their arm, and even us

1:01.4

mere humans can regrow our liver after losing more than half of its original mass. To make this magic

1:07.9

a bit closer to reality, I'm investigating how our body can heal wounds

1:12.6

and build tissue through instructions from the immune system.

1:16.6

From a scrape on your knee to that annoying sinus infection, our immune system defends our body

1:22.3

from danger. I'm an immunologist, and by using what I know about our body's defense system,

1:28.3

I was able to identify key players in our fight to build back our cuts and bruises.

1:33.3

When looking at materials that are currently being tested for their abilities to help regrow muscle,

1:38.3

our team noticed that after treating an injured muscle with these materials,

1:42.3

there was a large number of immune cells

1:44.8

in that material and the surrounding muscle. So in this case, instead of the immune cells

1:50.8

rushing off toward infection to fight bacteria, they're rushing toward an injury. I discovered a specific

1:57.6

type of immune cell, the helper T-cell, was present inside that material that I implanted

2:03.4

and absolutely critical for wound healing.

...

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