How to Slow Down Your Biological Aging – Morgan Levine, Ph.D. : 941

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

Nutrition, Fitness, Wellness, Fasting, Lifestyle, Meditation, Science, Brain, Hacking, Self-improvement, Fat, Biohacking, Health & Fitness, Education, Diet

4.6 • 7.4K Ratings

🗓️ 27 May 2022

⏱️ 70 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer’s. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.

We’re finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan.

“If you take the difference between someone’s biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says.

She’s an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging.

She’s also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.

Today, she’s going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly.

This conversation gets into topics and makes them make sense for your own aging, like:

Epigenetics & epigenetic clocks
DNA methylation & telomeres
Cell lifespan
Ageotypes (molecular assessment of aging)
Phenotypic age
The “Ceiling” effect
The “CALERIE” trial
Nutrition & aging (plants, fasting, ketosis)
Fitness & aging (energy & brain health)
Rest & relaxation (sleep & biological programming)

Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking.

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Transcript

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0:00.0	You're listening to the human upgrade with Dave Asprey.
0:06.0	Formerly, Bulletproof Radio.
0:11.0	You're listening to the human upgrade with Dave Asprey.
0:15.6	I promise you that I'm going to tell you what you're going to get in a show before the
0:19.3	show happens.
0:21.0	Because that way you can decide, do I want to pick another episode of the show or do
0:24.8	I want to go for this one?
0:26.6	In this episode, you're going to get information about biological age instead of chronological
0:32.1	age and why that's the primary risk factor for all of the four killers you might have
0:37.7	read about in my aging book.
0:39.1	Things like cancer, heart disease, diabetes, Alzheimer's.
0:44.0	I have to come out here on the show and say that I no longer identify with my chronological
0:53.5	age.
0:54.5	I identify with my biological age and I'm having a hard time finding biological age affirming
1:00.0	care from my medical providers.
1:02.8	If you're having a similar problem, you are not alone.
1:06.1	When you fill out a form and they make you state your physical age, even though that
1:11.7	physical age does not match your body the way you feel it, clearly that's ageism and
1:16.8	it's probably grounds for a lawsuit.
1:19.6	If you have an age descriptor on your field, clearly you're not honoring my biological age.
1:26.0	So instead of it being something that's just in my head, is there math?
1:30.5	Is there science?
	...

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