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The Human Upgrade: Biohacking for Longevity & Performance

How To Sculpt a Perfect Jawline WITHOUT Surgery : 1378

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

Science, Diet, Biohacking, Nutrition, Wellness, Hacking, Lifestyle, Fasting, Fat, Education, Health & Fitness, Meditation, Fitness, Brain, Self-improvement

4.67.3K Ratings

🗓️ 11 December 2025

⏱️ 54 minutes

🧾️ Download transcript

Summary

Your jaw influences far more than your face. This episode shows you how jaw strength shapes cognition, posture, airway health, sleep, metabolism, and overall human performance. You will learn how targeted jaw training increases cranial blood flow, improves neuromuscular coordination, strengthens airway stability, and stimulates facial muscles that modern diets no longer challenge. 


Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 


Host Dave Asprey talks with Brandon Harris, founder and CEO of Jawzrsize. Brandon developed the device after multiple severe injuries, including a shattered jaw, months of immobilization, and a 13 day coma. His recovery forced him to rebuild his jaw strength from zero and revealed how deeply the jaw affects posture, oral health, proprioception, and cognitive function. Brandon’s experience as a mixed martial artist and his early training of the masseter muscle guided the creation of a safe, medical grade jaw resistance system that now has small clinical data supporting improvements in strength, facial tone, Bruxism relief, and TMJ balance. 


You will hear how jaw alignment influences the nervous system, why weak jaws contribute to sleep apnea, how saliva flow ties oral health to gut health, and why resistance training for the jaw produces structural benefits the modern soft diet fails to provide. Host Dave Asprey explains how full range jaw training supports cranial stimulation, nitric oxide signaling, fascia activation, posture correction, and neuromuscular coordination throughout the body. This episode also explores how jaw mechanics connect to biohacking principles like brain optimization, sleep optimization, longevity, neuroplasticity, metabolic signaling, and strength based anti aging. 


This is essential listening for anyone focused on biohacking, human performance, posture mechanics, airway stability, TMJ function, oral microbiome health, anti aging, supplements that support structural function, nervous system training, and practical tools that create fast visible results.  


You’ll Learn: 

• Why jaw strength acts as a foundational marker for performance and longevity 

• How jaw alignment shapes posture, proprioception, and neuromuscular firing 

• Why weak jaws contribute to sleep apnea, snoring, and airway collapse 

• How jaw training improves Bruxism, clenching, and TMJ tension 

• What increased cranial blood flow does for cognition and focus 

• How saliva production supports oral and gut health 

• Why modern diets shrink facial structure and weaken masseter strength 

• How jaw resistance training improves facial tone and reduces wrinkle depth 

• Why athletes use jaw activation to sharpen hand eye coordination 

• How range of motion training strengthens bone through piezoelectric signaling 

• Why even five minutes a day creates noticeable results in facial tone and alignment 


Thank you to our sponsors! 

-HeartMath | Go to https://www.heartmath.com/dave to save 15% off. 

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. 


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. 


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 


Keywords: jaw strength training, TMJ alignment exercise, cranial blood flow stimulation, facial muscle resistance training, bruxism clenching relief, sleep apnea jaw support, oral microbiome improvement, saliva flow activation, jaw posture neuromuscular signaling, masseter hypertrophy training, facial tone anti aging, proprioception jaw connection, airway stability strengthening, hunters gatherers chewing mechanics, tongue plate neck activation, molar alignment biomechanics, jaw range of motion training, piezoelectric bone stimulation, oral health gut health pathway, forward jaw positioning airflow 


Resources:   

• Go to https://jawzrsize.com/ ‘Dave15’ for 15% off! 

• Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. 

• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  

• Danger Coffee: https://dangercoffee.com/discount/dave15   

• My Daily Supplements: SuppGrade Labs (15% Off)   

• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   

• Dave Asprey’s BEYOND Conference: https://beyondconference.com   

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  

• Upgrade Collective: https://www.ourupgradecollective.com   

• Upgrade Labs: https://upgradelabs.com   

• 40 Years of Zen: https://40yearsofzen.com   


Timestamps: 

0:00 - Trailer 

1:20 - Intro 

2:20 - Brandon’s Accident and Recovery 

5:00 - Jawzrsize Origin Story 

6:16 - The Science of Jaw Strength 

17:56 - Clinical Results and User Experience 

22:48 - Jaw Health, Posture and Systemic Effects 

27:54 - Microplastics 

35:59 - Athletic Performance and Neuromuscular Strength 

52:57 - Final Thoughts 

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Transcript

Click on a timestamp to play from that location

0:00.0

We have these Shaolin monks and they look scrawny, but they're doing one finger pushups,

0:05.3

and they're stronger than some of these guys who are just a wall of muscle.

0:08.3

And what you don't want to do is be like a big wall of muscle with no neurological strength backing it up.

0:13.2

But what you're pointing out with jawsercise is that you're getting neuromuscular strength

0:18.4

because the jaw is so tied into the nervous system, which is why you're saying

0:21.8

if people are doing their deadlift and they bite down on the jaws are sized, they're getting the

0:26.0

alignment right there. That alignment creates neurological strength and the neuromuscular connection.

0:31.3

You could literally take people in retirement homes and say, like, do this every day. And it would

0:35.3

have cognitive effects because of the blood flow,

0:37.8

and it would have nitric oxide effects, and probably even postural and other effects. And then my lady says, oh, my gosh, your sleep apnea is gone. And then I talked to my doctor about it. He says, well, the main cause of sleep apnea, or one of the main causes is a weak, lower jaw. Because it falls back at night, I guess. And this is one of those things, it's kind of a no-brainer.

0:55.9

It's not expensive, and it works. once it's a weak lower jaw. Because it falls back at night, I guess. And this is one of those things, it's kind of a no-brainer.

0:55.9

It's not expensive.

0:57.2

And it works.

0:59.4

You're listening to The Human Upgrade with Dave Asprey.

1:07.0

Giving gifts to loved ones is really good for your biology.

1:10.7

Studies show generosity improves mood, reduces anxiety, and increases your levels of feel-good neurotransmitters like oxytocin.

1:19.6

You can make meaningful gifting a breeze this year with my 20-25 holiday gift guide.

1:25.6

It's not just for biohackers. It's for anyone on your list who wants to look

1:29.4

good, feel good, and perform better. Real science backs every product on the list. I've tried and

1:35.4

tested each one and they deliver real noticeable results. The holidays are coming fast. Don't risk

1:42.0

giving another gift that ends up in a drawer, or worse, in the trash.

1:46.1

Go to Dave Asprey.com slash gift guide to explore the full guide. You'll find something cool for everyone on your list.

...

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