How Lifting Weights Affects Your Genetics w/ Dr. Kevin Murach, Anders Varner, and Doug Larson #748
Barbell Shrugged
Doug Larson
4.7 • 2.8K Ratings
🗓️ 22 May 2024
⏱️ 54 minutes
🧾️ Download transcript
Summary
Kevin A. Murach, Ph.D., received his undergraduate degree from the University of North Carolina at Chapel Hill, where he earned the Ronald Hyatt Scholarship in Exercise Science. After graduating, Dr. Murach completed a master’s degree in Exercise Physiology at James Madison University at Harrisonburg, Virginia, then earned his Ph.D. in Human Bioenergetics from the Ball State Human Performance Laboratory in Muncie, Indiana. His dissertation was a collaboration with NASA aimed at optimizing the exercise prescription for astronauts on the International Space Station.
After Ball State, Dr. Murach spent six years as a post-doctoral fellow/scholar at the University of Kentucky Center for Muscle Biology in Lexington under the guidance of Drs. Charlotte Peterson and John McCarthy. During this time, he was supported by two National Institutes of Health grants (F32 and K99), was recipient of the Thomas V. Getchell Memorial Award from the University of Kentucky Grant Writing Workshop, won the 2017 FASEB BioArt contest and was an NIH NIA Butler-Williams Scholar.He now is an assistant professor in the Department of Health, Human Performance and Recreation in the University of Arkansas College of Education and Health Professions.
His current research uses human muscle samples, primary cell culture and genetically modified mouse models to understand the molecular cues that drive exercise adaptations and aging, and the interaction between these two (among other things). In his free time, Dr. Murach enjoys spending time with his wife, Dr. Kyndal Murach, exercising, building custom watches, cooking, smoking meats and collecting bourbon.
He shared this preprint he recently posted: https://www.biorxiv.org/content/10.1101/2024.03.26.586857v1
Summary: This study investigated the molecular mechanisms underlying muscle recovery after exercise, focusing on the temporal dynamics of gene expression and DNA methylation. Biopsies of the vastus lateralis muscle were taken before and at various time points (30 minutes, 3 hours, 8 hours, and 24 hours) after resistance exercise (RE), along with a control group. RNA sequencing and DNA methylomics were employed to analyze gene expression and methylation patterns, respectively, complemented by computational methods.
Transcript
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| 0:00.0 | Shark Family this week on Barbell Shrug. We've got a special intro today, but on the main show today, |
| 0:05.4 | Dr. Kevin Murak is coming in and we are talking about how lifting weights affects your genes. |
| 0:12.2 | Very interesting conversation because a lot of times we just think we're going to go lift weights. |
| 0:16.0 | We're going to go to the gym and we're going to go get our pump on, build some muscle, go home at night. |
| 0:20.0 | What we don't ever think about is how that affects this little thing called epigenetics and how our genetics use lifting weights to turn on and off specific genes in our body that allow us to promote that muscle growth, |
| 0:34.7 | essentially creating an environment in which our genetics have to react to that |
| 0:39.8 | stimulus to create a bigger, stronger, more badass you. |
| 0:43.3 | But before we get into that show, |
| 0:44.9 | Coach Travis Smash is on the show because, |
| 0:47.1 | or into this intro, because he has a seminar coming up |
| 0:50.3 | on June 1st, correct? That's right, June 1st. |
| 0:54.0 | The 4th athlete. |
| 0:56.0 | The 4th athlete, the Coaches Clinic, |
| 0:58.0 | I think it's going to be the Premier Clinic for coaches in America. |
| 1:02.0 | We've got everything covered from speed to |
| 1:05.6 | nutrition with your boy Dan Garner to sleep and to sleep and recovery from |
| 1:10.5 | your boy Dr. Chris Berry has been on our show. |
| 1:13.0 | We got, you know, I already said speed, we've got strength with Dr. |
| 1:16.5 | Sucamil. |
| 1:17.5 | Of course, Joe Ken is going to be talking about movement, |
| 1:20.0 | and then I'll be talking about how to create the adaptation you're after. |
| 1:23.6 | And next week just for getting our audience caught up on Dr. Sue Camille, |
... |
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