How Ketones Burn Fat & Protect Muscle: Dr. Dominic D’Agostino

Optimal Protein Podcast with Vanessa Spina

Vanessa Spina

Fitness, Health & Fitness, Nutrition

4.5 • 758 Ratings

🗓️ 31 March 2025

⏱️ 89 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Timeline: Get 10% off Mitopure, clinically proven to boost mitophagy. Go to timeline.com/vanessa.

In this powerful episode of The Optimal Protein Podcast, host Vanessa interviews Dr. Dominic D’Agostino, one of the world’s leading researchers in ketogenic science and metabolic therapy.

They dive into how ketones not only serve as a powerful fuel source but also act as metabolic signaling molecules that promote fat loss, protect muscle, and support whole-body health.

Dr. D’Agostino shares why he personally pursues ketosis every day, how ketones interact with protein metabolism, and the key differences between nutritional and exogenous ketones. You’ll also learn how a high-protein ketogenic diet supports appetite regulation, body recomposition, and metabolic flexibility—especially for women in midlife.

If your goals include burning fat, preserving lean muscle, and optimizing energy and cognition, this episode is a must-listen.

🔍 Topics Covered:

• How and why Dr. D’Agostino gets into ketosis every day

• The truth about protein on a ketogenic diet

• Ketones and their impact on muscle protein synthesis and preservation

• Appetite suppression and satiety in a keto-adapted state

• Exogenous ketones: how and when to use them

• The synergy of strength training, protein, and ketones

• Why you test breath acetone ketones

• What the latest science says about ketosis for performance and metabolic health & the future of ketone research in aging, and more

Get 20% off on the Tone Device breath ketone analyzer OR the Tone LUX Crystal Red Light Therapy Mask Ketogenicgirl.com with the code VANESSA

Join the Community! Follow Vanessa on instagram to see her meals, recipes, informative posts and much more! Click here @ketogenicgirl

Follow @optimalproteinpodcast on Instagram to see visuals and posts mentioned on this podcast.

Link to join the facebook group for the podcast: https://www.facebook.com/groups/2017506024952802/

The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

🔗 Connect with Dr. D’Agostino:

• Website: https://www.ketonutrition.org

• Instagram: @dominic.dagostino.kt

• Twitter/X: @DominicDAgosti2

Transcript

Click on a timestamp to play from that location

0:00.0	Welcome to the Optimal Protein Podcast. I'm Vanessa Spina. Hello, my friends, welcome back to the podcast. I am so
0:09.3	excited to be here with you all today. We have the world's leading experts on ketones and keto and high
0:16.7	protein keto, Dr. Dominic Degasino joining us on the podcast again. He is so incredibly
0:22.5	knowledgeable. And on today's episode, we talk about some of our favorite topics, how he
0:27.2	personally does keto. Why does he personally pursue keto and having ketones and ketosis on a daily
0:33.6	basis? What exactly a high protein keto diet is, how he follows his high protein
0:40.1	keto diet in terms of macros on the protein, the fat, and the carb side. We talk about the effect
0:46.1	of ketosis on appetite suppression, on satiety, and how effective it is if you want to burn fat
0:52.9	and effectively recompose your body.
0:55.2	We also talk about the effects of ketones on muscle and muscle sparing and growing strength
1:01.0	and muscle, which is a topic of interest of his as well personally.
1:05.8	And we also talk about the incredible science behind all of it, as well as the effect of ketones on the brain
1:12.0	and cognition and how it has been rescuing my brain recently and why I've been taking
1:17.5	exogenous ketones. So many incredible topics in the episode today. I know you're going to get
1:22.7	at least a couple of takeaways and actionable takeaways that you can implement into your life. So I can't
1:29.3	wait to hear your thoughts on today's episode and we will jump right in after this quick break.
1:34.8	Friends, I want to tell you about a very important nutrient that many of us are deficient in
1:40.6	and not even aware of it. And that nutrient is light and specifically red light.
1:46.6	I am so passionate and obsessed with the incredible amount of science behind red light therapy's
1:53.6	ability to support our mitochondrial health. Now our mitochondria, as you probably know, are
1:58.6	responsible for helping us to do pretty much everything in our bodies
2:02.9	at the cellular level now when it comes to energy levels our immunity our skin health and beauty
	...

Please login to see the full transcript.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Vanessa Spina, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Vanessa Spina and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.