Well, good morning, good afternoon or good evening. Whatever time of the day it is that you're

listening to this, trying to take in a few clinical pharmacology pearls. This is the real-life

pharmacology podcast. I'm Eric Christensen, Pharmacist, board certified in geriatrics and pharmacotherapy,

and I'm going to try to relay some important information to you that may be advantageous in

real life practice as well as for your pharmacology final or your board exam, whatever

you're preparing for.

It should be helpful for that as well.

So today, covering diabetes

medication, GLP1 agonist, and we're going to look at the pharmacology a little bit, mechanism

of action, side effects, and drug interactions as well. So this class of drugs, so GLP-1 stands for glucagon-like peptide.

And remember that an agonist is a term that stimulates something.

So these GLP-1 agonists, these drugs, act similar in the body to incritin hormones.

And there's some really important things that these incritin hormones do,

and obviously this drug class does.

They can help kind of promote fullness, which can help reduce the appetite, which is a really huge

deal in our type 2 diabetes patients who are potentially or maybe likely overweight.

Also can kind of slow down the gastric emptying time.

So again, that's kind of that leads into the fact that it promotes that fullness

and a feeling of the stomach being filled up.

And then it can also increase glucose dependent secretion.

So this can really blunt what are called those post-pranidal blood sugars.

So those blood sugars after we eat, this drug can actually help stimulate that insulin secretion following a meal.

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