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BBC Inside Science

Gene-edited twins, Placenta organoids in a dish, When the last leaves drop

BBC Inside Science

BBC

Technology, Science

4.51.3K Ratings

🗓️ 29 November 2018

⏱️ 29 minutes

🧾️ Download transcript

Summary

Claims by a Chinese scientist that he has gene-edited human embryos, transplanted them producing genetically edited twins, who will pass on these changes to their offspring, has the scientific community outraged. The work, which was carried out in secret, has not been officially published or peer reviewed, but if the claims are to be taken seriously, this work severely flaunts international ethical guidelines at many levels. BBC Health and Science Correspondent James Gallagher explains the story so far. Little is known about the placenta and how it works, despite it being absolutely essential for supporting the baby as it grows inside the mother. When it doesn’t function properly, it can result in serious problems, from pre-eclampsia to miscarriage, with immediate and lifelong consequences for both mother and child. Our knowledge of this important organ is very limited because of a lack of good experimental models. Animals are too dissimilar to humans to provide a good model of placental development and implantation, and stem cell studies have largely proved unsuccessful. But one group of University Cambridge researchers have now created ‘mini-proto placentas’ – a cellular model, growing long-term, in 3D of the early stages of the placenta – that could provide a ‘window’ into early pregnancy and help transform our understanding of reproductive disorders. The Woodland Trust want you to tell them when you notice a tree, you regularly see, loses all of its leaves. Its part of their long term phonological study, Nature's Calendar . They hope to keep track of the effect of climate change on the timings of annual tree events.

Transcript

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0:00.0

Hey, it's Doleepa, and I'm at your service.

0:04.7

Join me as I serve up personal conversations with my sensational guests.

0:08.8

Do a leap interviews, Tim Cook.

0:11.2

Technology doesn't want to be good or bad.

0:15.0

It's in the hands of the creator.

0:16.7

It's not every day that I have the CEO of the world's biggest company in my living room.

0:20.7

If you're looking at your phone more than you're looking in someone's eyes,

0:24.6

you're doing the wrong thing.

0:26.0

Julie, at your service, listen to all episodes on BBC Sales. BBC Sounds, music radio podcasts.

0:36.0

You're listening to the podcast of Inside Science from BBC Radio 4,

0:40.0

first broadcast on the 29th of November 2018.

0:44.0

I'm Marnie Chasterton and Uf, it's all go in science this week.

0:49.0

Albert Einstein allegedly said,

0:52.0

two things are infinite, the universe and

0:54.1

human stupidity and I'm not sure about the universe. And this week's inside

0:58.8

science touches on both. There's a rousing update on scientists' efforts to explore one of the other planets in our

1:05.6

solar system. We've a request for you lot to start reporting naked trees for science,

1:11.7

and there's a stonking new tool that could help unravel some of the problems

1:15.8

that occur in one in ten pregnancies. But let's start with human folly. Is there a collective

1:22.4

noun for a group of furious scientists, a collider?

1:26.4

Ponder that as we hear from them.

1:28.8

This experiment is monstrous.

...

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