Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Eric Christensen.

Thank you so much for listening today. As always, go get your free PDF, reallife pharmacology.com.

I give a rundown of the top 200 drugs and some of the most important things that you're going to see in clinical practice, as well as things that are going to show up on

pharmacology and board exams as well. So again, simply an email. We'll get you that at

real-life pharmacology.com. Go get that free 31-page PDF. All right. So let's get into the drug

of the day today, and that is Jim Fibrozil.

Brand name of this medication is Lopid.

It is an anti-collesceral type medication.

Also, probably the most common I hear in practice, it's a fibrate type medication used in hyper-collesterolemia.

From a mechanism of action standpoint, I'll be honest, I had to go and look this up.

And, of course, I was justified in my knowledge of not knowing what this is,

in that the mechanism of action is not well understood.

And I've never ever recall in an exam being asked what the mechanism of action is for Jim Fibrozole.

It's because there's a bunch of theories on how it works,

and it has associations with potentially very low

density lipoprotein, so VLDL and different mechanisms that way potentially, but again, it's all

theories as to how the drug works. It's really not well understood.

So that explained potentially my knowledge gap there

and not knowing what the mechanism of action for Jim Fibrozel is.

Anyway, in clinical practice, where I see this medication used most often is elevated triglycerides.

So patients with very significantly elevated triglycerides, usually in the ballpark of, you know,

500 or higher, up to 800 to 1,000 plus, these patients are at potentially higher risk for pancreatitis.

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