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Science Quickly

From Drunken Stupor to Sober with One (Hormone) Shot

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 17 January 2024

⏱️ 10 minutes

🧾️ Download transcript

Summary

We all have our tricks for sobering up after a night of drunken revelry: maybe a pot of black coffee or an ice-cold shower. But for mice in a certain lab in Texas, all it takes is a shot. No, not more alcohol—it’s an injection of a hormone called fibroblast growth factor 21, or FGF21.  Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years.

0:11.0

Yachtold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program.

0:20.1

To learn more about Yachtolt, visit yawcult.co.j.p.

0:23.9

That's y-A-K-U-L-T-C-O-J-P.

0:28.4

When it comes to a guide for your gut, count on YacL.

0:41.6

This is Scientific Americans. Science Quickly. I'm Karen Hupkin.

0:52.0

We all have our tricks for sobering up after a night of drunken revelry. Maybe a pot of black coffee. or an ice-cold shower.

0:58.1

But for mice in a certain lab in Texas, all it takes is a shot.

1:03.0

No, not more alcohol.

1:04.6

It's an injection of a hormone called fibroblast growth factor 21, or FGF21.

1:10.5

A new study shows that a shot of FGF21, a hormone that regulates metabolic pathways,

1:16.7

gets intoxicated mice up and running, twice as fast as animals that are allowed to come

1:21.8

around on their own.

1:23.2

What's more?

1:24.3

Mice lacking FGF21 drink more and take longer to recover from alcohol's effects than

1:30.5

their hormonally competent counterparts. The findings appear in the journal, cell metabolism.

1:35.9

The genesis of this particular project was the finding from several laboratories that this

1:42.2

particular hormone that we work on FGF21 is induced dramatically

1:47.0

by ethanol. We wanted to know what does FGF21 do acutely in terms of response to ethanol.

1:57.0

Steve Cleaver is a professor of molecular biology at the University of Texas Southwestern Medical Center.

2:03.5

I run a lap jointly with this fellow.

...

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