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The Quanta Podcast

Fish Have a Brain Microbiome. Could Humans Have One Too?

The Quanta Podcast

Quanta Magazine

Physics, Life Sciences, Science

4.7640 Ratings

🗓️ 24 April 2025

⏱️ 16 minutes

🧾️ Download transcript

Summary

The discovery that other vertebrates have healthy, microbial brains is fueling the still controversial possibility that we might have them as well.

The post Fish Have a Brain Microbiome. Could Humans Have One Too? first appeared on Quanta Magazine

Transcript

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0:00.0

Welcome to the quantum science podcast.

0:09.0

Each episode, we bring you stories about developments in science and mathematics.

0:14.0

I'm Susan Vallett.

0:15.0

Bacteria are in, around, and all over us.

0:19.0

They thrive in almost every corner of the planet, from deep

0:22.7

sea hydrothermal vents to high up in the clouds, to the crevices of our ears, mouth,

0:27.9

nose, and gut. But scientists have long assumed that bacteria can't survive in

0:33.7

the human brain. But can they? That's next.

0:43.0

Quantum Magazine is an editorially independent online publication

0:47.3

supported by the Simon's Foundation

0:49.3

to enhance public understanding of science.

1:02.3

The thinking goes that the powerful blood-brain barrier keeps the brain mostly free from outside invaders. But are we sure that a healthy human brain doesn't

1:07.8

have a microbiome of its own? Over the last decade, initial studies have

1:12.5

presented conflicting evidence. The idea has remained controversial. After all, it's hard to obtain

1:18.9

healthy, uncontaminated human brain tissue that could be used to study possible microbial

1:24.5

inhabitants. Recently, a study published in science advances provided the

1:30.1

strongest evidence yet that a brain microbiome can and does exist in healthy vertebrates,

1:36.7

at least in fish. Researchers at the University of New Mexico discovered communities of bacteria

1:42.3

thriving in salmon and trout brains. Many of the microbial species

1:46.7

have special adaptations that allow them to survive in brain tissue, as well as techniques

1:52.5

to cross the protective blood-brain barrier. Matthew Ome is a physiologist who studies the human

1:59.3

microbiome at the University of Colorado Boulder and wasn't

...

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