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Science Weekly

First UK baby born with DNA from three people: what happens next?

Science Weekly

The Guardian

Science

4.21K Ratings

🗓️ 11 May 2023

⏱️ 16 minutes

🧾️ Download transcript

Summary

The pioneering IVF procedure known as mitochondrial donation therapy (MDT) could prevent children from being born with devastating mitochondrial diseases. Madeleine Finlay speaks to Prof Darren Griffin, an expert in genetic diseases and reproduction, about how MDT works, the ethical considerations attached, and what techniques like it could mean for the future of reproduction. Help support our independent journalism at theguardian.com/sciencepod

Transcript

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0:00.0

This week the Guardian broke the news of a first in the field of fertility science in the UK.

0:18.0

The first baby created from three genetic parents has been born in the UK. The breakthrough is aimed at stopping

0:24.9

a mother passing on defective genes to a child.

0:28.4

The pioneering technique developed by doctors at the Newcastle Fertility Center is known as mitochondrial donation treatment or MDT.

0:38.0

Mitochondria provide energy to the cell and fuel the body.

0:42.0

So when these are abnormal, a person can be severely affected.

0:46.2

This could be anything from brain damage, muscle wasting, heart failure to blindness.

0:57.0

Conditions can even be fatal within days or even hours of birth.

1:04.0

So this new technique holds a lot of promise for those impacted. But there are still plenty of unknowns about long-term outcomes,

1:08.0

what these changes could mean for subsequent generations

1:12.0

and how the technology could be applied in the future.

1:16.7

From the Guardian I'm Madeline Finley and this is Science Weekly.

1:35.3

Darren Griffin, you're a professor of genetics at the University of Kent and you've done lots of research into genetic diseases and reproduction. So I'm keen to understand how significant this news is that the first baby has been born in the

1:41.9

UK with DNA from three people.

1:44.8

Yeah, it's worth unpacking it a little bit because it's a technology that we've known

1:49.6

about for some time.

1:51.6

So I've been aware of it for about 10 years,

1:54.0

10 years, but it was been talked about before then.

1:58.0

In many ways, it's a very obvious thing to do.

2:01.0

The technology itself isn't a million miles from the so-called cloning technology, the nuclear

2:06.7

transfer.

2:07.9

We were certainly aware from conferences that this treatment was happening, we were certainly

...

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