Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Eric Christensen.

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All right.

The drug of the day today is Fomodidine.

Brand name of this medication is Pepsid.

This is what's called an H2 blocker.

Essentially, from a mechanism of action standpoint,

this drug blocks the action of histamine in stomach parietal cells.

So basically, physiologically, what happens is histamine binds H2 receptors in parietal cells

in the stomach.

And these cells, parietal cells, are responsible for secreting gastric acid. So when histamine binds these H2 receptors,

it stimulates the release of gastric acid, which lowers the pH. When we use Fomodidine,

it blocks those receptors so histamine can't bind.

Therefore, we have less acid secretion,

and it's going to help with symptoms of things like heartburn and gurd.

And that indeed is the primary use.

In my practice, that's probably 90 to 95% of the time. If I see Fomodidine, that's what it's being used for.

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