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The Briefing Room

Explainer: How do weight-loss drugs work?

The Briefing Room

BBC

News, News Commentary

4.8731 Ratings

🗓️ 7 February 2025

⏱️ 5 minutes

🧾️ Download transcript

Summary

A number of studies have shown the amazing weight loss potential of a new group of drugs, known to many by their brand names as Ozempic (which is for diabetes), Wegovy and Mounjaro. But how do these new drugs work? How were they discovered and who can use them? This is part of a new mini-series called the The Briefing Room Explainers. They’re short versions of previous episodes of the Briefing Room. Presenter: David Aaronovitch Producers: Charlotte McDonald, Kirsteen Knight and Beth Ashmead Latham Studio Manager: Neil Churchill Editor: Richard Vadon Production Co-ordinator: Gemma Ashman

Transcript

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0:00.0

BBC Sounds, Music, Radio, Podcasts.

0:05.2

Hello, David here with a new mini-series from the briefing room.

0:09.5

We're packaging up some bits you may have heard before on other programmes,

0:13.3

which are still very relevant,

0:15.0

so they can explain specific things that are going on in the world.

0:18.7

In today's briefing room explainer, weight loss drugs,

0:21.7

let's find out what these new drugs are and what they do. Here with me is John Wilding,

0:26.8

Professor of Medicine at the University of Liverpool. John Wilding, how do we define obese in this

0:33.1

country and what proportion of people are obese? And maybe then you can tell us how that's changed.

0:40.1

Obesity is a complex disease that's associated with an excess amount of body fat.

0:45.1

We've tended to use body mass index, which is your weight in kilograms divided by your height squared in meters.

0:53.4

And a body mass index above 30 is generally considered

0:56.5

to define obesity, although that has its limitations because it doesn't tell us about body fat.

1:03.4

In this country, if we look at that metric, about just under 30% of people will be living

1:10.0

with obesity and about another 20 to 30% will be

1:14.8

overweight, which would be defined as a body mass index above 25. John, I take it just as there's a

1:21.6

difference between being overweight and obese. There's a difference between being obese

1:25.4

and being severely obese. Yes, that's right. In fact, the WHO gives classification.

1:30.3

So a class 1 obesity, the lowest would be between a body mass index of 30 and 35,

1:36.3

class 2 between 35 and 40, and above 40 would be class 3,

1:40.3

or what we would generally call severe obesity,

1:43.3

which is very, very commonly associated with

...

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