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Huberman Lab

Essentials: Using Your Nervous System to Enhance Your Immune System

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.826.2K Ratings

🗓️ 25 September 2025

⏱️ 39 minutes

🧾️ Download transcript

Summary

In this Huberman Lab Essentials episode, I explain how the immune system defends against infection and describe the relationship between the immune and nervous systems. I discuss the immune system's three primary layers of defense, emphasizing how each contributes to protection from infection. I share practical tools to enhance immune function and accelerate recovery from sickness, including specific breathing patterns, sleep positioning and targeted supplementation. I also explore the powerful mind-body connection, showing how mindset and nervous system activation can directly influence the body's ability to heal. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Timestamps (0:00) Immune System & Nervous System (0:33) Immune System 101, Innate & Adaptive Immune Systems (8:03) Mucus & Microbiome, Tools: Nasal Breathing; Avoid Eyes; Ingest Fermented Foods (10:57) Sponsor: AG1 (12:04) Sickness Behavior & Vagus Nerve, Fever, Photophobia, Rest (16:43) Humoral Factors, Inflammatory Cytokines (18:14) Sleep & Enhancing Immune System, Glymphatic System, Tool: Elevate Feet (21:12) Sponsor: LMNT (22:44) Stress & Inflammation, Tool: Early Symptoms & Cyclic Hyperventilation (31:09) Positive Mindset & Immune Function, Dopamine (34:03) Electroacupuncture, Fascia, Catecholamines & Inflammation (36:22) Accelerating Recovery, Medication, Tool: Spirulina & Rhinitis (38:34) Recap & Key Takeaways Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable

0:05.8

science-based tools for mental health, physical health, and performance.

0:11.4

I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

0:17.5

Today we are discussing the immune system, And we are also discussing how the nervous system

0:23.4

can be used to activate and control the immune system.

0:27.6

The first topic we have to attack is the question

0:31.3

of what is the immune system and how does it work.

0:34.1

I'd like to just take a moment and do a sort of brief immune system 101. Really simple,

0:41.8

cover the basic elements of the immune system so that everyone listening or watching this can get

0:46.4

a clear sense of how the immune system functions and what its basic parts are. It's actually

0:52.6

really simple because it is truly elegant in design.

0:56.9

You have three main layers of defense

1:01.0

for your health.

1:03.1

And the first of those three is a physical barrier

1:07.0

that we call your skin.

1:08.9

And that might seem kind of obvious,

1:10.3

but everything about you is contained

1:13.5

in this compartment that is boundered by your skin.

1:18.4

If you've ever had a cut,

1:19.7

you essentially have a breach of the boundary

1:22.5

that is your immune system.

1:24.5

Still in category one, your body and your external surface, you have openings to that

...

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