Essentials: How to Optimize Your Hormones for Health & Vitality | Dr. Kyle Gillett

Huberman Lab

Scicomm Media

Life Sciences, Science, Health & Fitness

4.8 • 26.2K Ratings

🗓️ 25 December 2025

⏱️ 42 minutes

🔗️ Recording | iTunes | RSS

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Summary

In this Huberman Lab Essentials episode, my guest is Dr. Kyle Gillett, MD, a dual board-certified physician in family medicine and obesity medicine and an expert in optimizing hormone levels to improve overall health. We explain how to improve hormone levels across the lifespan in both men and women using behavioral, nutritional and exercise-based tools. We also discuss common clinical topics, including hormone testing, PCOS, hair loss, testosterone replacement therapy (TRT) and peptides, focusing on potential benefits, tradeoffs and risks. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Maui Nui: https://mauinuivenison.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Kyle Gillett (00:00:36) Hormone Health; Women vs Men, Tool: Hormone Testing (00:02:35) Tool: Big 6 Lifestyle Pillars to Optimize Hormone Health (00:04:32) Sponsor: AG1 (00:06:17) Diet, Individualization; Bloodwork & Frequency (00:07:20) Exercise, Zone 2 Cardio; Caloric Restriction (00:08:36) Intermittent Fasting, Growth Hormone, IGF-1 (00:11:05) Hormones & Sleep, Growth Hormone, Menopause, Andropause, TRT (00:13:28) Testosterone & Women, SHGB (00:15:19) Sponsor: Maui Nui (00:16:34) Dihydrotestosterone (DHT), Androgens; Turmeric & Black Pepper; Hair Loss (00:19:47) Polycystic Ovarian Syndrome (PCOS), Symptoms, Metformin, Inositol (00:23:13) Cannabis, Alcohol, Testosterone (00:24:48) Males & Testosterone, TRT, Prostate Cancer (00:26:04) Prolactin, Dopamine "Wave Pool", Tool: Casein & Gluten (00:27:23) Sponsor: Function (00:29:03) Social Relationships & Hormones, Tool: Planning for Crisis (00:31:02) Peptides, Growth Hormone & Risk; BPC 157, Sourcing & LPS (00:36:42) Melanotan, Uses & Risks (00:38:45) Spiritual Health, Interdisciplinary Health Integration (00:41:23) Caffeine & Hormones, Sleep; Acknowledgements Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance.
0:11.3	I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
0:17.3	And now for my discussion about hormone health and optimization with Dr. Kyle Gillette.
0:22.1	Dr. Gillette, welcome.
0:23.7	Thank you for having me.
0:25.1	Well, I'm super excited to talk to you.
0:27.4	You are an encyclopedia of knowledge about hormone health for men and for women across the
0:33.1	lifespan.
0:33.8	So I have many, many questions.
0:36.0	When someone comes to you as a patient, in terms of hormone health, what are the sorts of probe questions that you ask? And what are you looking for? And I ask this because I'd like people to be able to ask some of these very same questions for themselves. So when you do a physical exam and a history, you have a lot of different parts.
0:54.4	You have your history of present illness if they have a complaint.
0:57.1	Maybe the patient doesn't have a complaint.
0:59.5	In that case, things like their social history and their family history are extremely
1:03.5	important because that gives you an insight into their genetics and an insight into their
1:08.8	hormone health.
1:10.5	So a patient will tell me,
1:12.2	oh, I'm doing okay, but it helps to ask them, well, how are you now? Let's say the patient is 50.
1:17.3	How are you now versus when you were 20 and what has changed? So I've got the question a lot,
1:23.3	how do you get your doctor to order a better lab workup or to even include your basic hormones? And there's no magic answer to that. But what really helps is you tell them, you know, my energy is not as good as it used to be. My focus is not as good as it used to be. My athletic performance is not as good as it used to be. So you don't have to have a pathology in order for a lab to be
1:45.3	indicated. You just need to have that pertinent symptom. Would you say that using the approach you just
1:50.1	described, that it's equally effective for men and women? Or do you find that for one reason or another,
1:57.1	that men and women have different challenges and advantages in trying to access their
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