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The John Batchelor Show

EReplaceable You: Skin Grafts, Bioprinting Organs, and the Science of Replacement Anatomy. Mary Roach discusses how third-degree burns destroy regenerative cells, causing severe disfigurement unless patched with allografts (temporary substitutes like cada

The John Batchelor Show

John Batchelor

Society & Culture, Arts, News, Books

4.52.8K Ratings

🗓️ 18 October 2025

⏱️ 16 minutes

🧾️ Download transcript

Summary

Replaceable You: Skin Grafts, Bioprinting Organs, and the Science of Replacement Anatomy. Mary Roach discusses how third-degree burns destroy regenerative cells, causing severe disfigurement unless patched with allografts (temporary substitutes like cadaver or cod skin). Researchers are attempting to 3D print organs, currently in the "Wright Brothers stage," using specialized bio-ink and support gel. Xenotransplantation involves genetically editing pigs to grow human organs (chimerism) that the body would accept without rejection.
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Transcript

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0:00.0

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0:30.0

This is CBSI on the world. I'm John Batchel. Spending time with Mary Roach, the author.

0:36.1

Her new book, Replaceable You, Adventures in Human Anatomy. We travel to Chengdu, China,

0:43.8

and we meet researchers and medical personnel who are using living things, but living things that don't exist before they make them. They're called

0:48.7

Camara. What are they? How are they used? Where are they, Mary?

1:01.6

Sure. Well, in Chengdu, I was visiting researchers who were working on xenotransplantation,

1:09.1

which is genetically editing a pig in this case so that its heart is less reactive, so that you're knocking out a protein called the alpha-gal

1:13.7

protein that causes a very, very vigorous rejection from humans. So they're doing that. But in the

1:19.7

course of my visit and my conversation with these researchers, they mentioned work that a colleague

1:26.1

was doing called chimerism.

1:29.6

A chimera, if you're familiar with the word from mythology, it's a being that is two

1:38.8

parts at once, two different creatures at once. And so what, and chimerism is really just in its infancy.

1:46.6

I believe there is a rodent example that's been successfully created.

1:52.5

But what they're talking about is you're genetically editing, let's use the example of a pig again, because pigs tend to be used,

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