Episode 94: John Newman discusses how the ketogenic diet and fasting regulate the genes and pathways that control aging

STEM-Talk

Dawn Kernagis and Ken Ford

Natural Sciences, Health & Fitness, Nutrition, Alternative Health, Science

4.7 • 706 Ratings

🗓️ 27 August 2019

⏱️ 89 minutes

🔗️ Recording | iTunes | RSS

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Summary

Our guest today is Dr. John Newman, a geriatrician and researcher who is well-known for a 2017 study that found a ketogenic diet reduced the mid-life mortality of aging mice while also improving their memory and healthspan. John is an assistant professor at the Buck Institute for Research on Aging and a geriatrician in the Division of Geriatrics at the University of California, San Francisco. He also is a physician who works with older adults in the San Francisco VA Medical Center. At Buck, John studies the molecular details of how diet and fasting regulate the genes and pathways that control aging. He particularly focuses on the ketone body beta-hydroxybutyrate and how its molecular signaling activities involving epigenetics and inflammation regulate aging and memory in mice.

Transcript

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0:00.0	Welcome to STEM Talk.
0:01.0	Stem Talk.
0:02.0	Stem Talk.
0:03.0	Stem Talk.
0:04.0	Stem Talk, where we introduce you to fascinating people who passionately inhabit the scientific
0:11.0	and technical frontiers of our society.
0:14.0	Hi, I'm your host, Don Cornagus, and joining me to introduce today's podcast as Man Behind the Curtain,
0:19.0	Dr. Ken Ford, IHMC's Director and of the double secret selection committee that selects all the guests who appear on STEM Talk.
0:26.6	Hi, Don. Great to be here today.
0:29.0	So our guest today is Dr. John Newman, who is an assistant professor at the Buck Institute for research on aging and a geriatrician in the division of geriatrics at the University of California, San Francisco, San Francisco,
0:39.3	and John also is a physician who works with older adults in the San Francisco VA Medical Center.
0:44.3	So at Buck, John studies the molecular details of how diet and fasting regulate the genes and pathways that control aging.
0:50.3	In particular, he focuses on the ketone body beta-hydroxybutyrate and its molecular
0:55.4	signaling activities. In a 2017 study, John led a teen that found a ketogenic diet reduced
1:00.9	the midlife mortality of aging mice and also improve their memory and health span.
1:05.7	But before we get to today's interview with John, we have some housekeeping to take care of. First, we really
1:13.3	appreciate all of you who have subscribed to STEMTOT. And we are especially appreciative of all
1:19.9	of the wonderful five-star reviews. As always, the double secret selection committee has been
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