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STEM-Talk

Episode 65: Dr. Brendan Egan talks about the importance of muscle and his research into exogenous ketones

STEM-Talk

Dawn Kernagis and Ken Ford

Health & Fitness, Nutrition, Science, Natural Sciences, Alternative Health

4.6 • 694 Ratings

🗓️ 5 June 2018

⏱️ 76 minutes

🧾️ Download transcript

Summary

Dr. Brendan Egan is an Associate Professor of Sport and  Exercise Physiology at Dublin City University who is well known for research that shows resistance training can improve strength, muscle mass, reduce falls in older people, and perhaps even extend lifespans. In addition to being a first-class researcher, Brendan is also a stand-out player in Ireland’s national sport, Gaelic football. His current research is exploring the synergy between nutrition and exercise interventions to optimize performance in athletes and the elderly. Current projects also involve protein hydrolysates in recovery and glycemic management; leucine and n-3 PUFAs in the elderly; and exogenous ketones and athletic performance. Links:  Brendan Egan’s faculty page:  https://dcu.academic.ie/live/!W_VALOCAL_DCU_PORTAL.PROFILE?WPBPRSN=1631629 Brendan Egan’s Researchgate profile https://www.researchgate.net/profile/Brendan_Egan2/contributions Brendan Egan’s TEDx talk: https://youtu.be/LkXwfTsqQgQ Exercise Metabolism and the Molecular Regulation of Skeletal Muscle Adaptation https://www.sciencedirect.com/science/article/pii/S1550413112005037 Metabolism of ketone bodies during exercise and training: https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP273185 Fueling performance: Ketones Enter the Mix: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30438-7 Does Strength-Promoting Exercise Confer Unique Health Benefits? https://academic.oup.com/aje/article-abstract/187/5/1102/4582884?redirectedFrom=fulltext Does Strength-Promoting Exercise Confer Unique Health Benefits? https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP275938 Show notes: 2:46: Dawn opens by mentioning that Brendan was born in Detroit, and that his Irish father moved the family to Ireland when Brendan was 3 years old. Dawn asks if Brendan’s mother was American. 4:09: Dawn comments on how Brendan was very athletic as a child and played Gaelic football, which is Ireland’s national sport, and asks if he could explain how this game is played. 6:02: Ken, following up on the last question, asks what Brendan’s training is like for this sport, and how he manages to fit it into his busy schedule as a professor. 7:41: Dawn asks if it is true that even though Brendan’s best grades were in math and physics, he never considered a career in science while he was in high school. 8:37: Dawn mentions that Brendan ended up at the University of Limerick after graduating, asking what made him decide to attend Limerick as well as what prompted him to major in sports and exercise science. 9:46: Dawn asks about two people, Phil Jakeman and John Kirwan, who played a big role in shaping Brendan’s education at Limerick. 11:58: Dawn comments on how after completing his bachelor’s of science degree, Brendan went to work on his master’s, heading to the UK and attending Loughborough University where he graduated with distinction in sports exercise and nutrition. Dawn asks what made him decide to attend Loughborough, and what stood out about his time there. 13:33: Dawn mentions that Brendan returned to Ireland in 2004 to start his doctoral studies under the supervision of Dr. Donal J O'Gorman at Dublin City University. Dawn asks what that experience was like. 15:06: Ken asks what Brendan learned from his research with Dr. O’Gorman, which focused on skeletal muscle adaptation to exercise and, in particular, continuity between acute molecular responses to individual bouts of exercise and the adaptations in skeletal muscle induced by exercise training. 18:30: Dawn asks what took Brendan to Karolinska Institute in Stockholm. 19:51: Brendan talks about his work at Karolinska using animal intravenous cell systems, and his research into transcriptional regulation of skeletal muscle insulin resistance and type 2 diabetes utilizing small non-coding RNA’s. 23:39: Ken mentions that Brendan’s first faculty posit...

Transcript

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0:00.0

Welcome to STEM Talk.

0:01.1

Stem Talk.

0:02.0

Stem Talk.

0:03.0

Stem Talk.

0:04.0

Stem Talk, where we introduce you to fascinating people who passionately inhabit the scientific and technical frontiers of our society.

0:14.0

Hi, I'm your host, Don Cornagus, and joining me to introduce today's podcast as the Man Behind the Curtain, Dr. Ken Ford,

0:20.0

IHMC's director and chairman of the double secret selection committee that selects all the guests who appear on STEM Talk.

0:25.6

Hi, Dawn. Great to be here.

0:27.6

Dr. Brendan Egan is Associate Professor of Sport and Exercise Physiology at Dublin City University.

0:33.6

He is perhaps best known for research that shows resistance training can improve strength,

0:39.3

muscle mass, and reduce the incidence of falls and fractures in older people, perhaps even

0:43.3

extend lifespans.

0:45.3

His current research interests concern the nutritional enhancement of performance across the

0:50.3

lifespan and the molecular regulation of skeletal muscle function and adaptation in exercise,

0:57.0

health, and aging.

0:58.7

But before we get to today's interview with Brendan, we have some housekeeping to take care of.

1:03.1

First, we really appreciate all of you who have subscribed to STEM Talk, and we are especially

1:07.8

appreciative of all the wonderful five-star reviews that are piling up on iTunes.

1:11.5

As we announced in several earlier episodes, the double secret selection committee has been

1:15.9

continually and carefully reviewing the iTunes reviews with an eye towards selecting the wittiest

1:20.4

and most lavishly praised-filled reviews to read on STEM Talk.

1:23.5

As always, if you hear your review read on STEM Talk, just contact us at STEMTalk at IHMC.

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