The opinions expressed in the following episode do not necessarily reflect those of the minds of madness podcast.

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Who are you and what have you done with my wife?

It's the kind of rhetorical question asked and just expressing pleasant surprise when someone has a change in behavior or attitude.

But what if it wasn't a rhetorical question? What if someone believed their spouse had been replaced by someone else and imposter a look alike?

Suddenly, who are you and what have you done with my wife?

Takes a much darker and more sinister tone? Join me now as we look at the tragic and bizarre murder of Caroline Coffey.

You'll hear how an incredibly rare mental disorder was blamed for distorting her husband's perception of reality, causing a psychotic break.

Or was he just a cold-blooded killer who invented a convenient excuse?

In the heart of upstate New York lies one of America's truly hidden gems, the city of Ithaca. Located at the southern end of Kuga Lake, it's a cosmopolitan oasis among the breathtaking rural landscape and seasonal beauty of the Finger Lakes region.

Central to the city's unique culture and character is Cornell University, an Ivy League school that has attracted some of the most brilliant minds from every corner of the globe since 1865.

Ithaca constantly ranks as one of America's best college towns and is often called the Little Apple by Locals.

Meaning, it has all the good of New York City, but none of the bad. Its big city vibrance wrapped in a cozy blanket of small town charm.

Imagine a portrait of Andy Warhol painted by Norman Rockwell and you start to get the idea. But it's not just what's in the city that makes it special. It's what's around.

Glaciation during the last ice age created a unique topography of gorges, lakes, rivers and hills. More than 100 waterfalls located within just 10 miles of downtown.

In short, it's a veritable outdoor paradise. It was this uncommon blend of recreation and research that attracted two Cornell students, Caroline Caffe and Blasje Cod, Tathaca, New York.

In 2009, 28-year-old Caroline Caffe was a postdoctoral researcher at Cornell's College of Veterinary Medicine.

After completing her PhD in comparative biomedical sciences in 2007, she was now a respected and promising young researcher working to find a cure for cancer.

The work she was doing at Cornell in the race to find a cure was on the absolute cutting edge of what was possible to accomplish using stem cells.

Caroline's newlywed husband was 24-year-old Blasje Cod, a computer whiz from New Zealand, who was pursuing his doctorate in information science.

Beyond academics, the couple took advantage of the outdoor lifestyle afforded by their surroundings in Ithaca. Despite their overly busy schedules, they made it a priority to carve out some time each day for physical fitness.

Routinely running along the myriad trails surrounding their apartment also gave them the added bonus of getting to spend some quality time together each day.

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