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Nutrition Facts with Dr. Greger

Epigenetic Clocks

Nutrition Facts with Dr. Greger

Michael Greger, M.D. FACLM

Nutrition, Alternative Health, Health & Fitness

4.83.7K Ratings

🗓️ 19 December 2024

⏱️ 17 minutes

🧾️ Download transcript

Summary

Do you know your biological age? This episode features audio from:

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Transcript

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0:00.0

Have you ever wondered if there's a natural way to lower your high blood pressure,

0:05.1

guard against Alzheimer's, lose weight, feel better?

0:07.7

Well, it turns out there is.

0:10.7

Welcome to the Nutrition Facts Podcast.

0:12.7

I'm your host, Dr. Michael Greger.

0:16.6

You can't buy an epigenetic clock, but you can use one to measure the age of your tissues

0:21.7

and cells and to protect health outcomes and life expectancy.

0:25.6

In our first story, we look at how epigenetics have surpassed telomere length as the

0:30.6

best age predictor.

0:32.6

Epigenetics, the differential expression of genes both establishes the character and function

0:38.7

of a cell and maintains that identity over time through round after round of cell division.

0:44.6

So our heart cell stays a heart cell and divides to make more heart cells instead of

0:49.0

skin cells or kidney cells, even though all of our main cells have the same entire complement of DNA to potentially

0:56.6

be anything.

0:58.3

This is accomplished by methylation chemical markers that silence inappropriate genes

1:03.3

in a particular cell.

1:04.5

The fidelity of that maintenance of methylation is good, 97 percent to 99.9 percent

1:10.3

every division, but not perfect.

1:12.6

Over time, those tiny errors may add up and may help explain why the methylation

1:18.6

patterns of identical twins drift apart as they age.

1:22.6

The epigenetic markers of young identical twins are essentially indistinguishable, but then diverge

1:28.7

over time. Identical twins have the same DNA, the same genes, but the difference in gene

...

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