Ep 131 Parkinson’s Disease: Dopamine & discoveries

This Podcast Will Kill You

Exactly Right and iHeartPodcasts

Health & Fitness, Science

4.8 • 17.1K Ratings

🗓️ 19 December 2023

⏱️ 106 minutes

🔗️ Recording | iTunes | RSS

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Summary

Parkinson’s is a disease of many dimensions. On the shelves of any bookstore or library you’ll find at least a handful of titles exploring the topic from a myriad of perspectives, and extending that search to the internet will turn up dozens upon dozens more options: how-to guides for the recently diagnosed, in-depth textbooks exploring the neurophysiology of disease development, memoirs about caregiving for people with Parkinson’s, books offering a tour through the history of research advancements. The choices seem limitless and maybe a tad overwhelming. But that’s where we come in. In this episode, we take you through many of the dimensions of Parkinson’s disease, from its complicated biology, still shrouded in mystery, to its history, peppered with transformative moments like the introduction of dopamine. We round out the episode by exploring the tremendous amount of promising research on the horizon, leaving us feeling like we’re *this* close to yet another revolution in Parkinson’s disease treatment. If you’ve ever wondered what dopamine does, who Parkinson was, and what might be next for this disease, this episode is for you.

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Transcript

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0:00.0	This is exactly right.
0:06.0	Many put their hope in Dr. Serhat.
0:09.0	His company was worth half a billion dollars.
0:11.0	His research promised groundbreaking treatments for
0:14.3	HIV and cancer, but the brilliant doctor was hiding a secret. You can listen to
0:20.0	Dr Death, bad magic, exclusively an ad free by subscribing to Wendry Plus in the Wendry app.
0:27.0	My name is Stacy. I'm 35 years old and at the age of 29 I was diagnosed with Parkinson's disease
0:36.1	specifically something called young onset Parkinson's disease.
0:40.6	I'm a doctor living in Australia and my first symptoms were a tremor in my left hand and I remember
0:49.1	very clearly one day I was just finishing up a case in the operating theater and my consultant
0:56.1	commented that my left hand was a little bit shakier than usual and had asked if I've
1:01.9	had extra coffee that day.
1:04.1	I didn't really think anything of it.
1:06.2	And then a couple weeks later,
1:08.9	I remember getting the odd weird muscle twitch and again not really thinking anything of it and then
1:18.1	one day I just couldn't tie surgical knots with my left hand which was something I had spent a lot of time trying to learn and had been able to do just as well as my right hand and suddenly all of the sudden, all of the sudden sudden I became quite clumsy and then over time I started getting just a little bit more symptoms, a little bit more twitching, getting cramps on and off, and all on my left hand's eye.
1:45.0	And then so I had mentioned this to my flatmate, who was also a doctor,
1:50.0	and he told me that I needed to go see the J-P, which is what I should have done a while ago.
1:58.7	But I finally went and I got referred to a neurologist and the neurologist said it's likely a mess given the fact you're female and young and so I was sent for an MRI on, and I had an MR on, I think a week or two later, and then went to see the neurologist again in the
2:19.5	I was perfectly clear.
2:21.5	The neurologist wasn't sure what was going on.
2:26.0	Thought it might be an essential charmer,
	...

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