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Science Quickly

Drugged Gut Microbiome Cuts Heart Risk in Mice

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 21 December 2015

⏱️ 3 minutes

🧾️ Download transcript

Summary

A compound found in extra virgin olive oil and red wine reduced mice’s risk of clogged arteries. Christopher Intagliata reports Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years.

0:11.0

Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program.

0:19.6

To learn more about Yachtolt, visit yawcult.co.

0:22.7

.jp.j. That's Y-A-K-U-L-T.C-O.J-P. When it comes to a guide for your gut, count on Yacolt.

0:33.6

This is Scientific American's 60-second science. I'm Christopher Entagata. Got a minute?

0:39.5

The microbes in our gut play a big role in helping us digest our food.

0:43.6

But as they break down nutrients, they also generate secondary compounds that can influence our health.

0:49.6

Take carnitine or letheison, substances found in red meat.

0:53.4

When your gut microbes break them down, the bugs excrete the waste product trimethylamine,

0:57.9

or TMA, which your liver enzymes convert to trimethelamine and oxide, TMAO,

1:04.1

and that substance ups the risk of heart disease.

1:07.1

But the effect isn't limited to red meat eaters.

1:09.6

We're constantly feeding our gut microbes these compounds.

1:13.7

And even the most ardent, vegetarian or vegan, it happens.

1:17.4

Stanley Hazen, a physician in preventive cardiology at Cleveland Clinic.

1:21.1

Every time you eat, even when you eat a pickle or a cucumber or, you know, a pure piece of lettuce,

1:26.7

once you eat something, your gallbladder

1:28.7

contracts and squirts some bile into the intestines to try to help digest the food. And even bile,

1:36.2

he says, has compounds like lethison that gut microbes digest into TMA. So why not block the gut

1:42.9

microbes from making TMA in the first place?

1:46.1

Hazen and his colleagues found a substance that does just that. It's a kind of butanol called

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