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Huberman Lab

Dr. Rhonda Patrick: Micronutrients for Health & Longevity | Episode 70

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.826.2K Ratings

🗓️ 2 May 2022

⏱️ 170 minutes

🧾️ Download transcript

Summary

My guest is Rhonda Patrick, Ph.D. She earned her doctoral degree in biomedical science from St. Jude Children’s Research Hospital at the University of Tennessee Health Science Center and has become one of the leading public health educators on the brain and general health, aging, cancer, and nutrition. We discuss the four major categories of micronutrients that regulate cellular and organ stress and antioxidants, inflammation, hormone regulation, immune system, and longevity. Dr. Patrick provides actionable protocols for obtaining key micronutrients from food and/or supplement-based sources. Additionally, Dr. Patrick outlines protocols for deliberate cold and deliberate heat exposure to benefit metabolism, cardiorespiratory fitness, mental health, and lifespan. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Maui Nui: https://mauinuivenison.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Dr. Rhonda Patrick – Micronutrients, Cold & Heat Exposure (00:03:12) Momentous Supplements (00:05:30) Sponsors (00:09:42) Stress Response Pathways, Hormesis (00:16:38) Plants, Polyphenols, Sulforaphane (00:21:12) Tools 1: Sulforaphane - Broccoli Sprouts, Broccoli, Mustard Seed (00:23:50) Tool 2: Moringa & Nrf2 Antioxidant Response (00:25:25) Sulforaphane: Antioxidants (Glutathione) & Air Pollution (Benzene Elimination) (00:27:10) Plants & Stress Response Pathways, Intermittent Challenges (00:29:35) Traumatic Brain Injury, Sulforaphane, Nrf2 (00:35:08) Tools 3: Omega-3 Fatty Acids (ALA, EPA & DHA), Fish Oil, Oxidation (00:48:40) EPA Omega-3s & Depression (00:52:02) Krill Oil vs. Fish Oil Supplements? (00:54:23) Benefits of Omega-3 Fatty Acids, Omega-3 Index & Life Expectancy (00:59:24) Tool 4: Food Sources of EPA Omega-3s (01:06:07) Omega-3 Supplementation, Omega-3 Index Testing (01:10:22) Benefits of Omega-3s (01:14:40) Tool 5: Food Sources of DHA Omega-3s (01:17:07) Vitamin D & Sun Skin Exposure (01:22:18) Role of Vitamin D, Gene Regulation (01:25:30) Tool 6: Vitamin D Testing & Vitamin D3 Supplementation (01:33:15) Tool 7: Skin Surface Area & Sun Exposure, Vitamin D (01:34:23) Vitamin D & Longevity (01:36:46) Sun Exposure & Sunscreen (01:40:30) Role of Magnesium, Magnesium Sources, Dark Leafy Green Vegetables (01:44:50) Tool 8: Magnesium Supplements: Citrate, Threonate, Malate, Bisglycinate (01:50:57) Tool 9: Deliberate Cold Exposure Protocol & Mood/Anxiety (01:59:22) Tool 10: Cold Exposure, Mitochondria UCP1 & Heat Generation (02:02:30) Tool 11: Cold & Fat ‘Browning’, PGC-1alpha, Metabolism (02:05:08) Cold Exposure & High-Intensity Interval Training (HIIT), PGC-1alpha, Muscle (02:08:04) Tools 12: Exercise, HIIT, Tabata & Sauna (02:13:30) Tool 13: Sauna, Endorphins/Dynorphins, Mood (02:17:45) Tool 14: Mild Stress, Adrenaline & Memory (02:19:53) Sauna, Vasodilation & Alzheimer’s and Dementia Risk (02:25:30) Sauna Benefits, Cardiorespiratory Fitness, Heat Shock Proteins (HSPs) (02:31:29) Insulin signaling, FOXO3 & Longevity (02:33:22) Tools 16: Sauna Protocols, Hot Baths & Fertility (02:37:41) Tool 17: Exercise & Longevity, Osteocalcin (02:41:37) Tools 18: Red Light Sauna? Infrared Sauna? Sauna & Sweating of Heavy Metals (02:47:20) FoundMyFitness Podcast, Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Huberman Lab on Instagram & Twitter Title Card Photo Credit: Mike Blabac Disclaimer

Transcript

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0:00.0

Welcome to the Huberman Lab podcast where we discuss science and science-based tools for everyday life.

0:09.0

I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

0:15.0

Today my guest is Dr. Rhonda Patrick.

0:17.0

Dr. Patrick is known to some of you as a podcaster and one of the premier educators in the landscape of mitochondria, metabolism, stress, and other aspects of brain and body health.

0:29.0

Her podcast Found My Fitness is one of the premier podcasts in the world for disseminating knowledge about how the brain and body work and how we can use behavioral tools, microtutrients, supplements, and other protocols in order to maximize our immediate and long-term health.

0:46.0

Dr. Patrick did her formal training in cell biology exploring the links between mitochondrial metabolism apoptosis, which is naturally occurring cell death, which is a healthy form of cell death that occurs in our brain and body.

0:58.0

Throughout the lifespan and cancer biology.

1:02.0

She then went on to do postdoctoral training with Dr. Bruce Ames investigating the effects of micronutrients, meaning vitamins and minerals, and how they affect metabolism, inflammation, DNA damage, and the aging process.

1:15.0

She has published landmark review articles and primary research, meaning original research articles in some of the premier journals in the world including science, nature cell biology, trends in cell biology, and facep.

1:27.0

Indeed, Dr. Patrick is an expert in an extraordinarily broad range of topics that impact our health.

1:34.0

For today's episode, we focus primarily on the major categories of micronutrients that are essential for brain and body health.

1:41.0

I have to confess that before the discussion with Dr. Patrick, I was aware of only one of the categories of micronutrients that we discuss.

1:48.0

You'll notice that I am wrapped with attention throughout the discussion, and I think that you'll want to have a pen and paper handy because she offers not only a very clear understanding of the biological mechanisms by which other micronutrients operate, but some very clear and actionable tools and items that we can all embark on if we are to optimize our brain and body health.

2:12.0

We also discuss behavioral protocols. Dr. Patrick is well known for her understanding of the scientific literature on sauna and the use of heat and cold for optimizing things like metabolism, longevity, cardiovascular health, and I've delayed to say that we discussed that as well, and how behavioral protocols can interface with supplement based and nutritional protocols.

2:34.0

I'm confident that you'll learn a tremendous amount of information from Dr. Patrick, much of which is immediately actionable. If you're not already following and listening to her excellent podcast, you'll absolutely want to do that.

2:46.0

It's foundmyfitness.com is the website where you can get access to that podcast. It's also on Apple and Spotify and YouTube as foundmyfitness.

2:55.0

Dr. Patrick also has a terrific newsletter that I recommend signing up for. It's foundmyfitness.com slash newsletter is where you'll find it. And it includes research on fasting, microtrub nutrient sleep, depression, fitness longevity, and far more along, of course, with actionable protocols.

3:12.0

I'm pleased to announce that the Hubertman Lab podcast is now partnered with momentous supplements.

3:17.0

Our motivation for partnering with momentous is to provide people one location where they can go to access the highest quality supplements in the specific dosages that are best supported by the scientific research and that are discussed during various episodes of the Hubertman Lab podcast.

3:33.0

If you go to livemomentous.com slash Hubertman, you will see those formulations. I should mention that we are going to add more formulations in the months to come.

3:42.0

And you will see specific suggestions about how best to take those supplements, meaning what dosages and times of day. And in fact, how to combine those supplements with specific behavioral protocols that have been discussed on the podcast and are science supported in order to drive the maximum benefit from those supplements.

4:01.0

And many of you will probably also be pleased to learn that momentous ships not just within the United States, but also internationally.

...

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