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Huberman Lab

Dr. Justin Sonnenburg: How to Build, Maintain & Repair Gut Health

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.826.2K Ratings

🗓️ 7 March 2022

⏱️ 133 minutes

🧾️ Download transcript

Summary

My guest this episode is Dr. Justin Sonnenburg, Professor of Microbiology & Immunology at Stanford University. Dr. Sonnenburg’s research focuses on how microbes in our gut impact our mental and physical health and how diet and your environment shape your gut microbiome. We discuss the architecture of the gut microbiome and microbiota variability in different regions of the gastrointestinal (GI) tract and how these can change in response to diet, environment or genetics. We explore the early establishment of your microbiome and how your mode of delivery into the world (C-section or not) shapes your gut. We also discuss lifestyle factors that can alter your microbiome and the integral role the gut microbiome plays in communicating to other organs, including your brain. Dr. Sonnenburg details his recent clinical study, which found that diets rich in fermented foods (but not fiber) increase microbiota diversity and reduce signals of inflammation. Additionally, we examine how foods typical in Western Diets (e.g., high fat, low fiber, processed foods) can negatively impact the gut microbiome. Throughout the episode, we discuss actionable tools from peer-reviewed clinical findings that anyone can implement, regardless of budget, in order to optimize their gut microbiome and health. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Thesis: https://takethesis.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) Dr. Justin Sonnenburg, Gut Microbiome (00:04:16) Sponsors (00:08:30) What is the Gut Microbiome? (00:12:49) Gastrointestinal (GI) Tract & Microbiota Variability (00:16:00) Breast Feeding, C-Sections & Pets (00:21:56) The Human Microbiome Project at Stanford (00:26:30) Traditional vs. Industrialized Populations (00:28:58) Resilience of the Microbiome (00:35:10) Regional Differences Along Your GI Tract (00:42:04) Fasting, Cleanses & Gut Health (00:51:19) Dietary Differences (01:01:24) Simple vs. Complex Carbohydrates, Processed Foods (01:07:03) Artificial & Plant-based Sweeteners (01:12:44) Cleanses: Useful? Harmful? (01:14:50) Your Microbiome & Your Immune System (01:20:17) Dietary Fiber & Fermented Foods (01:32:13) High-Fiber vs. High-Fermented Diet; Inflammation (01:41:33) Ripple Effects of a Healthy Diet (01:45:00) Does a High-Fiber Diet Make Inflammation Worse? (01:47:22) Over Sterilized Environments (01:50:15) The Gut Microbiome’s Effect on Physiology (01:56:45) Gut-Brain Connection (01:59:30) Probiotics: Benefits & Risks (02:04:20) Prebiotics: Essential? (02:07:00) Tools for Enhancing Your Gut Microbiota (02:11:12) Dr. Sonnenburg’s Research, Zero-Cost Support, YouTube, Spotify, Apple Reviews, Sponsors, Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Transcript

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0:00.0

Welcome to the Huberman Lab podcast where we discuss science and science-based tools for everyday life.

0:09.0

I'm Andrew Huberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

0:15.0

Today my guest is Dr. Justin Saunenberg.

0:18.0

Dr. Saunenberg is a professor of microbiology and immunology at Stanford School of Medicine

0:23.0

and one of the world's leading experts on the gut microbiome.

0:26.0

The gut microbiome is the existence of trillions of little microorganisms throughout your gut.

0:33.0

And by your gut I don't just mean your stomach, I mean your entire digestive tract.

0:38.0

Turns out we also have a microbiome that exists in our nose, in any other location in which our body interfaces with the outside world.

0:47.0

In fact there's a microbiome on your skin and while it might seem kind of intrusive or kind of disgusting to have all these little microorganisms,

0:54.0

they can be immensely beneficial for our health, meaning our hormonal health, our brain health and our immune system function.

1:02.0

Dr. Saunenberg teaches us about the gut microbiome, how it's organized, especially meaning which microbiota live where he teaches us about these incredible things called crypts and niches,

1:12.0

which are little caves within our digestive tract that certain microbiota take residence and at that premiere real estate they're able to do incredible things to support our health.

1:20.0

He also talks about the things that we can all do to support our microbiome in order for our microbiome to support our brain and body health.

1:29.0

Dr. Saunenberg co-runs his laboratory with his spouse, Dr. Erica Saunenberg, and together they've also written a terrific and highly informative book called The Good Gut,

1:39.0

taking control of your weight, your mood and your long term health.

1:42.0

Even though that book was written a few years back, the information still holds up very nicely.

1:46.0

And today he also builds on that information informing us about recent studies that for instance point to the important role of fermented foods and the role of fiber in supporting a healthy gut microbiome.

1:59.0

So if you heard about the gut microbiome or even if you haven't, today you're going to hear about it from one of the world's leading experts, he makes it immensely clear as to what it is, how it functions and how to support it for your brain and body health.

2:12.0

During today's discussion, we don't just talk about nutrition, we also talk about the impact of behaviors and the microbiome.

2:20.0

Behaviors such as who you touch, who you kiss, who you hug, whether or not you interact with or avoid animals, whether or not those animals belong to you, or whether or not they belong to somebody else.

2:29.0

If all that sounds a little bit bizarre, you'll soon understand that your microbiome is constantly being modified by the behavioral interactions, the nutritional interactions, and indeed your mood and internal reactions to the outside world.

2:43.0

This is an incredible system. Everyone has one. Everyone should know how it works and everyone should know how to optimize it. And today you're going to learn all of that from Dr. Saunenberg.

...

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