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Huberman Lab

Dr. David Linden: Life, Death & the Neuroscience of Your Unique Experience

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.826.2K Ratings

🗓️ 21 August 2023

⏱️ 157 minutes

🧾️ Download transcript

Summary

In this episode, my guest is Dr. David Linden, Ph.D., professor of neuroscience at Johns Hopkins University School of Medicine and the author of many popular books about the brain. We discuss individual differences between people — focusing on differences in how people sense the world around them and the roles that chance, heredity, and life experiences (even in utero) play in determining our physical and cognitive traits. We discuss the bidirectional connection between the mind and body and how our thoughts and mental practices (e.g., meditation and breathwork) impact our health. We also discuss the link between inflammation and depression. We also discuss Dr. Linden’s terminal illness diagnosis, his mindset during chemotherapy and what his diagnosis has taught him about the mind, gratitude, time perception and life. This episode also covers sensual touch, cerebellar function, and epigenetic inheritance and ought to be of interest to all interested in neuroscience, genetics, psychology and human development. For the full show notes, including articles, books, and other resources, visit hubermanlab.com. Take our survey and get 2 months of Huberman Lab Premium Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Levels: https://levels.link/huberman InsideTracker: https://insidetracker.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Timestamps (00:00:00) David Linden (00:03:59) Sponsors: ROKA & Levels; Huberman Lab Survey (00:07:54) Sensory Touch & Genitals, Krause Corpuscles (00:16:46) Sexual Experiences & Sensation (00:19:14) Human Individuality & Variation; Senses & Odor Detection (00:30:25) Sponsor: AG1 (00:31:22) Visual Individuality; Heat Tolerance; Early Life Experiences & Variation (00:40:28) Auditory Variability, Perfect Pitch (00:42:08) Heritability & Human Individuality: Cognitive & Physical Traits (00:49:36) Heritability, Environment, Personality; Twin Studies (01:00:12) Sponsor: InsideTracker (01:01:19) Development, Chance; Transgenerational Epigenetic Inheritance (01:07:37) Single Generation Epigenetic Inheritance & Stress; Autism (01:15:52) Sleep Paralysis; Cerebellum, Prediction (01:23:47) Nature vs. Nature, Experience; Linden Hypothesis (01:30:37) Mind-Body Interaction; Chemical Signals (01:39:10) Inflammation & Depression (01:43:35) Neuroplasticity, Inflammation & Mental Disorders; Microglial Cells, Exercise (01:52:15) Fads & Science (01:55:16) Mind-Body Communication; Cancer (02:03:28) Mind-Body, Mediation, Breathwork (02:07:30) Atrial Fibrillation, Synovial Sarcoma, Heart (02:14:22) Gratitude & Anger; Chemotherapy, Curiosity & Time Perception (02:19:58) Death, Brain & Future Prediction, Religion & Afterlife (02:24:15) Life Advice; Time Perception & Gratitude (02:34:35) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Transcript

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0:00.0

Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life.

0:08.7

I'm Andrew Huberman, and I'm a professor of neurobiology and

0:12.4

Ophthalmology at Stanford School of Medicine. Today my guest is Dr. David Linden.

0:17.2

Dr. David Linden is a professor of neuroscience at Johns Hopkins School of Medicine. His laboratory has studied

0:22.8

neuroplasticity, that is, how connections in the brain change in response to experience.

0:28.2

Much of that work focused on a structure called the cerebellum,

0:31.6

which is also sometimes referred to as the mini-brain, because it looks like a mini-brain in the bottom and back of the human brain,

0:38.3

and it's responsible for an enormous number of basic functions that we use in everyday life, including our

0:43.6

motor behavior. That is our ability to walk and talk, but also dance, play instruments, and it's responsible for an enormous number of basic functions

0:51.1

that we use in everyday life, including our sense of balance, our ability to learn new motor behaviors,

0:57.5

as well as our sense of timing. Today we will discuss the cerebellum in what it does,

1:01.9

but Dr. David Linden will also teach us about the important sense of touch, as well as what makes us different as individuals.

1:09.6

The reason today's discussion encompasses so many important topics is that Dr. David Linden's laboratory has focused on many of those topics,

1:17.1

and he is also the author of five excellent popular books about neuroscience that focus on, for instance,

1:23.6

our sense of pleasure, and where it originates from, and what controls it in the brain, as well as our sense of touch.

1:29.7

And today we start off our discussion by talking about the recent discovery of a set of neurons that have been known about for a long period of time,

1:37.9

but that only recently have been characterized that are involved in

1:41.8

sensual touch in particular, and it's a fascinating conversation, I assure you. In addition to that, Dr. David Linden informs us about what makes us

1:49.9

individuals. How each and every one of us perceives the same things differently, and it's an absolutely fascinating conversation,

1:57.2

which tells you, for instance, why some of you think a smell is putrid, indeed, smells like vomit, whereas others, perhaps,

2:04.5

are not bothered by that smell, and why others still are attracted to that smell, or something that you look at, or something that you hear.

2:12.8

We also talk about nature versus nurture, and how we come to be who we are, not just through our genes and epigenetics,

...

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