Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist,

Eric Christensen. Thank you so much for listening today. As always, if you haven't, go check

out Real Life Pharmacology.com. Get your free 31-page PDF on the top 200 drugs. It's a great study

guide or a great refresher if you're out in practice, so I know a lot of pharmacology students have taken advantage of that free resource.

So go check that out.

Simply an email.

We'll get you access to that at real-life pharmacology.com.

All right.

Let's get into the drug of the day today.

And that is Diclofenac.

Brand name of this medication is Volteran.

And I'm going to primarily focus on oral administration of Diclofenac for this episode.

So keep in mind the absorption from using the topical agent is much, much less than using the oral agent, obviously.

So some of the side effects that show up at higher, higher risk for oral systemic administration may not be quite as true if we're giving the topical agent there.

So when I'm discussing this, I just wanted to lay that out and say, hey, I'm reviewing

oral and systemic adverse effects with this medication in this episode, and I'll potentially do DiClofenac gel in a future episode.

All right.

So this medication is an analgesic.

It's an insed.

And mechanistically, how insides work is they inhibit Cox 1 and Cox 2 enzymes

and ultimately reduce prostate glandin synthesis.

Now, there's a few different prostaglandins,

...