Hello and welcome to the Zero to Finals podcast. My name is Tom and in this episode I'm going to be talking you through Diabetes Incipidus.

If you want to follow along with written notes on this topic, you can follow along at 0.com slash diabetes insipidus or in the endocrinology section of the zero to finals medicine book.

Let's get straight into it.

Diabetes insipidus is caused by either a lack of antidiuretic hormone or ADH

or a lack of response to antidiuretic hormone.

Remember that antidioretic hormone acts on the collecting

ducks in the kidneys and allows them to reabsorb water from the urine. So having diabetes

insipidus prevents the kidneys from being able to concentrate the urine and this leads to polyurea or

excessive amounts of urine and polyda, or excessive amounts of urine,

and polydipsia, or excessive thirst, because the blood is so concentrated.

It can either be classified as nephrogenic or cranial diabetes insipidus,

depending on whether the problem is in the kidneys or in the brain,

and a key differential diagnosis of diabetes insipidus is primary polydipsia.

And this is where the patient has a normally functioning ADHD system,

but they're drinking excessive quantities of water,

and this is leading to excessive urine production.

They don't have diabetes insipidus,

but they present with polyurea and often polydipsia.

Firstly, let's talk about nephrogenic diabetes insipidus,

and this is where the collecting ducks of the kidneys

don't respond to the ADHD that's in the bloodstream.

And this can be caused by a number of different factors.

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