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Curiosity Weekly

Customizing the Human Race with CRISPR-Cas9 Genome Editing Technology

Curiosity Weekly

Warner Bros. Discovery

Science

4.6963 Ratings

🗓️ 31 October 2017

⏱️ 56 minutes

🧾️ Download transcript

Summary

CRISPR technology could change the world. Essentially, CRISPR is a technique that allows scientists to make precision edits to any DNA, whether bacterial or human. The potential for this technology is huge: if scientists have the accuracy to replace just a few faulty genes, it might be possible to cure genetic disorders as serious as cystic fibrosis and Huntington's disease and as common as lactose intolerance and color-blindness. Dr. Sam Sternberg, CRISPR expert and protein-RNA biochemist, joins the Curiosity Podcast to explain the science, ethics, and future of this cutting-edge technology.

Samuel H. Sternberg, PhD, will be starting his own research laboratory at Columbia University in early 2018, as an assistant professor in the Department of Biochemistry and Molecular Biophysics. Along with Jennifer Doudna, he is the co-author of A Crack in Creation, a popular science book about the discovery, development, and applications of CRISPR-Cas9 gene editing technology.

Additional resources discussed:

Follow Curiosity Daily on your favorite podcast app to get smarter with Cody Gough and Ashley Hamer — for free! Still curious? Get exclusive science shows, nature documentaries, and more real-life entertainment on discovery+! Go to https://discoveryplus.com/curiosity to start your 7-day free trial. discovery+ is currently only available for US subscribers.

 

Full episode transcript here: https://curiosity-daily-4e53644e.simplecast.com/episodes/customizing-the-human-race-with-crispr-cas9-genome-editing-technology


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Transcript

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0:00.0

Hi, I'm Cody Gough with the award-winning curiosity.com, and today we're going to talk about the future of the human race.

0:07.0

I'm Ashley Hamer, and yes, today's topic really is that big of a deal.

0:12.8

What if you could customize your children?

0:14.9

Pick their eye in hair color or eliminate genetic diseases?

0:18.3

Or what if you could rewrite DNA

0:20.5

to improve intelligence or athletic ability both in humans and in animals?

0:26.0

Science fiction is becoming reality thanks to a technique called CRISPR-CAS-9 and today we'll talk to a

0:31.4

leading expert about what's next for that cutting-edge science.

0:34.6

Every week we explore what we don't know because curiosity makes you smarter.

0:38.3

This is the Curiosity Podcast. Today we're going to talk with Dr. Sam Sternberg, an assistant professor in the Biochemistry and Molecular

0:54.3

Biophysics department at Columbia University, and we're going to be talking about

0:58.6

CRISPR-KAS9 technology, which is one of his specialties.

1:02.7

But before we dive into today's interview, I was hoping that Ashley can help us understand

1:07.1

a little bit about what CRISPR-KAS9 is to set the stage.

1:10.1

Yeah, it's really exciting stuff, but it's also really complex.

1:14.4

So CRISPR is a technique for editing DNA, which is the blueprint behind every cell in your body.

1:19.4

When you can edit DNA, you can potentially change anything about an organism, whether that's making a

1:24.2

potato healthier or reducing an embryo's risk of genetic diseases or even fighting cancer

1:28.8

in a living human.

1:29.8

So when you edit DNA, does that edit every cell in your body's DNA or just certain cells?

1:36.7

So that depends on what you're doing it to.

1:39.9

If you do it to an embryo, you can potentially change every single cell in that embryo's body.

...

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