Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, pharmacist, Eric Christensen.

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go to real-life pharmacology.com and snag that free resource right there. All right, so let's

talk about the drug of the day today, and that is going to be Colchazine.

Brand name of this medication is Colchris.

That's the most common brand name that I hear in clinical practice anyway.

And this medication does have a bunch of unique uses. However, 99% of the time,

the indication that I see this medication used for is gout. That is mostly what I'm going to focus on.

There's things like Mediterranean fever. There has been

potentially some evidence in reducing cardiovascular risk as a secondary prevention type agent.

I can't say at the time I'm creating this podcast that I'm real you know, real sold on the evidence and the risk versus

benefit of doing that. But that may be something that you see more evidence on going forward

in the future. But again, I'm going to focus mainly on that gout indication.

So mechanistically, how does it work?

It blocks beta tubuline polymerization into microtubules, which ultimately reduces the activation or activity of neutrophils.

Okay.

And in gout, remember, inflammation plays a huge role in the pain associated with a gout flare.

Nutrivils are really going to facilitate and exacerbate that inflammation and pain.

So again, by kind of reducing that activation, activity of those neutrophils,

we can help manage symptoms of a gout flare.

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