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Science Quickly

Cellular Circuit Computes with DNA

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 1 April 2016

⏱️ 3 minutes

🧾️ Download transcript

Summary

Researchers have created what they call the first "programming language" for cells, which compiles code into a genetic circuit. Christopher Intagliata reports. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years.

0:11.0

Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program.

0:19.6

To learn more about Yachtolt, visit yawcult.co.

0:22.7

.jp. That's Y-A-K-U-L-T.C-O.J-P. When it comes to a guide for your gut, count on Yacult.

0:33.6

This is Scientific American's 60-second science. I'm Christopher Entagata. Got a minute?

0:39.9

Our smartphones, tablets, laptops, they all compute things electronically. But think outside that

0:45.9

silicon box for a second. There's nothing special about electrons in using silicon as part of

0:52.7

computing. Chris Voigt, a bioengineer at MIT.

0:56.2

You can do computing with any number of things.

0:58.8

Including, he says, DNA.

1:00.8

Cells do computing all the time,

1:03.3

so they're constantly trying to interpret their environment

1:07.5

and be able to turn on different genes and respond to it.

1:11.4

And those genes in a cellular circuit, they're like the logic gates, the memory, and other

1:16.1

systems found in conventional computers.

1:18.9

So Void and his colleagues created what he calls the first human-made programming language for

1:23.8

living cells.

1:24.8

It's an open-source design environment called cello.

1:28.7

You just write what you want the cell to do, and cell spits out the DNA sequence, as if you were compiling code. The researchers

1:34.7

used the platform to design 60 genetic circuits, which they then ran inside E. coli bacteria.

1:40.8

And many of these DNA-based circuits allow bacteria to sense environmental data, like the levels of oxygen or glucose in the gut, and respond in various ways.

...

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