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Unexplainable

Can ovaries make new eggs?

Unexplainable

Vox

Life Sciences, Science, Natural Sciences

4.52K Ratings

🗓️ 17 August 2022

⏱️ 28 minutes

🧾️ Download transcript

Summary

There's an old story scientists tell about human ovaries: that they are ticking clocks that only lose eggs, never gain them. Now that story might be changing, opening the door to new treatments for infertility and menopause. For more, go to http://vox.com/unexplainable It’s a great place to view show transcripts and read more about the topics on our show. Also, email us! [email protected] We read every email. Support Unexplainable by making a financial contribution to Vox! bit.ly/givepodcasts Learn more about your ad choices. Visit podcastchoices.com/adchoices Learn more about your ad choices. Visit podcastchoices.com/adchoices

Transcript

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0:00.0

It's unexplainable. I'm no, I'm Hassan Feld. Roughly half the human population has ovaries.

0:09.7

Researchers know they generally come in pairs that they're about the size of cum quats,

0:14.2

shaped like almonds, and that they hold eggs that if they're fertilized can eventually turn

0:19.6

into children. But as a reporter, Bird Pinkerton learned, there's a whole lot researchers

0:25.3

don't know about ovaries. And in order to answer those questions, they might need a rollback

0:30.6

the clock on decades of assumptions. Here's Bird. If you took high school biology, you probably

0:37.9

read in your biology textbook somewhere, some version of a specific story we tell about our ovaries.

0:47.1

So the story starts in utero, Rachel Gross. It's my favorite human biology textbook,

0:53.2

she's a friend, but also a reproductive health reporter. And she gave me a refresher course.

0:59.0

She said that in utero, a fetus is developing limbs and an eyes, but also a bunch of eggs

1:06.7

until the baby is born with maybe around one to two million. And as the story goes,

1:13.2

that is all the eggs that this new little person will ever have.

1:18.4

From the beginning, those eggs start dying off. A few of them are disappearing even as the baby

1:25.5

becomes a child, though most of them are just sort of hanging out, not doing a whole lot.

1:31.0

Until the hormone surges and cycles of puberty start that monthly cycle that many of us know,

1:38.8

called opulation and menstruation. And in that cycle, there's kind of a cohort of the sleeping,

1:45.6

tiny eggs that are recruited. These recruits then start growing. And at 1.1A is ahead of the pack

1:53.3

and starts helping inhibit the other eggs, which I'll die. The winning egg then takes a little

1:58.8

trip through the fallopian tubes, maybe gets fertilized, probably not. And if not, it gets ejected

2:05.2

in the delightfully bloody, sometimes crampy, usually pretty annoying phase of menstruation,

2:12.4

known as a period. Each month or so, the ovaries are losing a bunch of eggs this way,

2:18.0

and then other eggs are also just dying on their own. In your 30s and 40s, the process of eggs

...

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