Bypassing Surgery: An Oral Pill for the Treatment of Morbid Obesity—Hasan Celiker—Xeno Biosciences

Finding Genius Podcast

Richard Jacobs

Medicine, Health & Fitness

4.4 • 1K Ratings

🗓️ 15 November 2018

⏱️ 31 minutes

🔗️ Recording | iTunes | RSS

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Summary

Gastric bypass surgery is the most effective form of treatment for morbid obesity and a familiar term to most of us, but until recently, the underlying mechanism that makes it so successful has been largely misunderstood. Most people—including health professionals—attribute the weight loss that follows from this surgery to reduced stomach size and therefore reduced food intake and malabsorption, but the evidence is pointing elsewhere: to the changes in gut microbiota that occur after the surgery.

Hasan Celiker is the founder and chief executive officer of Xeno Biosciences, a company that's using what they've learned about the effectiveness of gastric bypass surgery to develop an alternative and significantly less invasive form of treatment for obesity: an oral pill that mimics the changes in gut microbiota that occur after the surgery, allowing for weight loss and a significant reduction in conditions associated with obesity, such as diabetes and fatty liver disease.

Celiker delves into the details of digestive mechanisms, the differences between aerobic and anaerobic bacteria and the role of each in the microbiome, how and where in the body Xeno Bioscience's pill takes effect, and the metabolic changes brought about by both the pill and the surgery. Hit play and visit xenobiosciences.com to learn more.

Transcript

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0:00.0	Welcome to Almost Here, Around the Corner of Future Technology Podcasts with Richard Jacobs.
0:07.0	Future Technologies is to transform our lives for better or worse or the focus of this podcast.
0:13.0	Almost here means these technologies are now here and starting to be used.
0:17.0	Or just around the corner, for Bitcoin to artificial intelligence,
0:21.0	3D printing, blockchain, virtual reality, and more.
0:25.0	Hello, this is Richard Jacobs with the Future Tech and Future Tech Health
0:31.3	podcast. I guess today is Hassan or Hassan Selaker, the founder and chief
0:36.4	executive officer of Xenobiosciences.
0:39.7	Hassan, how you doing?
0:41.1	Good Richard, how are you?
0:42.4	Thanks for having me.
0:44.0	Yeah, so Zeno Bio-Siances sounds like a Zeno sounds like foreign or alien.
0:49.0	What's the premise to the company?
0:51.0	Yeah, so it's, you know, it's related to the company. Yeah, so it's you know it's related to the microbiome so and the idea of the name is that
0:56.7	Zeno means a guest of foreign and that you know that's related to the guests that we have in our guts and also kind of related to our product, the drug that we're producing because it's oxygen and you know zeno contains or letters that are in oxygen
1:17.7	essentially so that was the premise of the name but yeah so I can tell you a little bit about what we're trying to do. You know, so what we're trying to do is we're developing an oral pill to treat obesity and it mimics the changes in the
1:37.1	gut microbiot that will occur after gasey-fry-fast surgery and we believe that's the main reason why the surgery causes
1:44.9	weight loss there's this substantial shift in the structure of the microbes
1:49.9	that live in your gut and there's this you, just to give you a bit of a background
1:55.2	on the surgery, so this is gastric bypass surgery.
1:58.3	It's a great loss surgery.
2:00.5	It's a profoundly effective intervention and it's actually the most effective
	...

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